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ALDH2 AntibodyPurified Mouse Monoclonal Antibody (Mab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AM1831a | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
| AM1831a-ev20 | 20 ug 100 ul | In Stock | $ 95.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
- Protocols
- Backgrounds
ALDH2 Antibody - Product info | |
| Application | WB, IHC, FC, IF
|
| Primary Accession | P05091 |
| Other Accession | NP_000681 |
| Reactivity | Human |
| Concentration | 0.25 mg/ml |
| Isotype | IgG1,Ig? |
| Clone Names | 138CT22.3.8 |
| Calculated MW | 56381 Da |
ALDH2 Antibody - Additional info | |
| Gene ID 217 | |
| Other Names ALDH2; ALDM; Aldehyde dehydrogenase, mitochondrial; ALDH class 2; ALDH-E2; ALDHI | |
| Target/Specificity This ALDH2 Monoclonal antibody is generated from mouse immunized with ALDH2 recombinant protein. | |
| Dilution WB~~1:100~1000 IHC~~1:50~100 FC~~1:10~50 IF~~1:10~50 | |
| Format Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions ALDH2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. | |
ALDH2 Antibody - Protein Information | |
| Name ALDH2 | |
| Synonyms ALDM | |
| Cellular Location Mitochondrion matrix. | |
ALDH2 Antibody - Related products
AP1432a: ALDH2 Antibody (N-term)
AP1432c: ALDH2 Antibody (Center)
RI10230: ALDH2 predesign siRNA
DC01195: Human ALDH2 cDNA Clone
LY11659a: ALDH2 Over-expression Lysate
ALDH2 Antibody - Application data
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Western blot analysis of ALDH2 monoclonal antibody (Cat. #AM1831a) in HepG2 cell line lysates (35ug/lane). ALDH2 (arrow) was detected using the purified mab.(4ug/ml)
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ALDH2 Monoclonal Antibody (Cat. #AM1831a) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the ALDH2 Monoclonal Antibody for immunohistochemistry. Clinical relevance has not been evaluated.
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ALDH2 Monoclonal Antibody (Cat. #AM1831a) flow cytometric analysis of HepG2 cells (right histogram) compared to a negative control cell (left histogram).PE-conjugated goat-anti-mouse secondary antibodies were used for the analysis.
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Confocal immunofluorescent analysis of ALDH2 Antibody (Cat#AM1831a) with HepG2 cell followed by Alexa Fluor 488-conjugated goat anti-mouse lgG (green). DAPI was used to stain the cell nuclear (blue).
ALDH2 Antibody - Research Areas
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BACKGROUND
This protein belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of this enzyme, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of Orientals have only the cytosolic isozyme, missing the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among Orientals than among Caucasians could be related to the absence of the mitochondrial isozyme. This gene encodes a mitochondrial isoform, which has a low Km for acetaldehydes, and is localized in mitochondrial matrix.
REFERENCES
Relationship between genetic polymorphisms of ALDH2 and ADH1B and esophageal cancer risk: a meta-analysis. Yang SJ, et al. World J Gastroenterol, 2010 Sep 7. PMID 20806441. Effects of alcohol-drinking behaviour and ADH1B and ALDH2 polymorphisms on basal DNA damage in human mononuclear cells as determined by the comet assay. Weng H, et al. Mutat Res, 2010 Aug 30. PMID 20685249. Evaluation of a brief web-based genetic feedback intervention for reducing alcohol-related health risks associated with ALDH2. Hendershot CS, et al. Ann Behav Med, 2010 Aug. PMID 20652463. Association of genetic polymorphisms of aldehyde dehydrogenase-2 with esophageal squamous cell dysplasia. Zhou YZ, et al. World J Gastroenterol, 2010 Jul 21. PMID 20632450. Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086.
