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>   home   >   Products   >   Primary Antibodies   >   DLG4 Antibody (C-term) (Rat) (Ascites)   

DLG4 Antibody (C-term) (Rat) (Ascites)

Mouse Monoclonal Antibody (Mab)

  • WB - DLG4 Antibody (C-term) (Rat) (Ascites) AM1833b
    Western blot analysis of RAT DLG4 Antibody (C-term) (Cat. #AM1833b) in mouse cerebellum tissue lysates (35μg/lane).DLG4 (arrow) was detected using the purified Mab.(1:100)
  • IHC-P - DLG4 Antibody (C-term) (Rat) (Ascites) AM1833b
    RAT DLG4 Antibody (C-term)(Ascites) (Cat. #AM1833b) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjμgation of the secondary antibody and DAB staining. This data demonstrates the use of the RAT DLG4 Antibody (C-term)(Ascites) for immunohistochemistry. Clinical relevance has not been evaluated.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P31016
Other Accession Q62108, P78352
Reactivity Human, Mouse
Host Mouse
Clonality Monoclonal
Isotype IgM
Clone Names 127CT15.8.20
Calculated MW 80465 Da
Antigen Region 677-706 aa
Additional Information
Gene ID 29495
Other Names Disks large homolog 4, Postsynaptic density protein 95, PSD-95, Synapse-associated protein 90, SAP-90, SAP90, Dlg4, Dlgh4, Psd95
Target/Specificity This DLG4 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 677-706 amino acids from the C-terminal region of human DLG4.
Dilution WB~~1:100~500
Format Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsDLG4 Antibody (C-term) (Rat) (Ascites) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Dlg4
Synonyms Dlgh4, Psd95
Function Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B.
Cellular Location Cell membrane; Peripheral membrane protein. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell junction, synapse. Membrane. Cell projection, axon. Note=High levels in postsynaptic density of neurons in the forebrain. Also in presynaptic region of inhibitory synapses formed by cerebellar basket cells on axon hillocks of Purkinje cells
Tissue Location Detected in juxtaparanodal zones in the central nervous system and at nerve terminal plexuses of basket cells in the cerebellum (PubMed:20089912). Detected in brain (at protein level). Brain. Highest levels of isoform 2 in cerebellum, cortex, hippocampus, and corpus striatum
Citations (0)

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a molecular scaffolding protein that binds and clusters N-methyl-D-aspartate receptors at neuronal synapses; may be involved in guanine nucleotide-mediated signal transduction pathway [RGD]


SAP102 is a highly mobile MAGUK in spines. Zheng CY, et al. J Neurosci, 2010 Mar 31. PMID 20357126. Synaptic clustering of PSD-95 is regulated by c-Abl through tyrosine phosphorylation. de Arce KP, et al. J Neurosci, 2010 Mar 10. PMID 20220006. Transduced PDZ1 domain of PSD-95 decreases Src phosphorylation and increases nNOS (Ser847) phosphorylation contributing to neuroprotection after cerebral ischemia. Wang WW, et al. Brain Res, 2010 Apr 30. PMID 20197063. Hidden dynamic allostery in a PDZ domain. Petit CM, et al. Proc Natl Acad Sci U S A, 2009 Oct 27. PMID 19828436. Integrin-linked kinase is involved in cocaine sensitization by regulating PSD-95 and synapsin I expression and GluR1 Ser845 phosphorylation. Chen Q, et al. J Mol Neurosci, 2010 Mar. PMID 19629758.

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$ 295.00
Cat# AM1833b
(40 western blots)
Availability: In Stock
Bulk Size
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