|Application ||WB, E|
|Calculated MW||14960 Da|
|Other Names||Acyl-coenzyme A thioesterase 13, Acyl-CoA thioesterase 13, 312-, Thioesterase superfamily member 2, Acyl-coenzyme A thioesterase 13, N-terminally processed, ACOT13, THEM2|
|Target/Specificity||This THEM2 monoclonal antibody is generated from mouse immunized with THEM2 recombinant protein.|
|Format||Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||THEM2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates. Can also hydrolyze 3- hydroxyphenylacetyl-CoA and 3,4-dihydroxyphenylacetyl-CoA (in vitro). May play a role in controlling adaptive thermogenesis (By similarity).|
|Cellular Location||Cytoplasm, cytosol. Mitochondrion. Nucleus. Cytoplasm, cytoskeleton, spindle. Note=During interphase, found both in the nucleus and in the cytoplasm. At mitosis, localizes to the spindle. Colocalizes with tubulin (By similarity)|
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Provided below are standard protocols that you may find useful for product applications.
THEM2 belongs to the UPF0152 (paaI) family. Its exact function is still undetermined.
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