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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   HSPA1A Antibody   

HSPA1A Antibody

Mouse Monoclonal Antibody (Mab)

  • WB - HSPA1A Antibody AM1877b
    HSPA1A antibody (Cat. #AM1877b) western blot analysis in HL-60 cell line lysates (35μg/lane).This demonstrates the HSPA1A antibody detected the HSPA1A protein (arrow).
  • IF - HSPA1A Antibody AM1877b
    Confocal immunofluorescent analysis of HSPA1A Antibody (Cat#AM1877b) with Hela cell followed by Alexa Fluor® 488-conjugated goat anti-mouse lgG (green). DAPI was used to stain the cell nuclear (blue).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P08107
Other Accession Q6S4N2, Q27965, P34930, Q27975, NP_005336.3
Reactivity Human
Predicted Bovine, Pig
Host Mouse
Clonality Monoclonal
Isotype IgG1,K
Clone Names 201CT8.2.3
Calculated MW 70052 Da
Antigen Region 574-600 aa
Additional Information
Gene ID 3303;3304
Other Names Heat shock 70 kDa protein 1A/1B, Heat shock 70 kDa protein 1/2, HSP70-1/HSP70-2, HSP701/HSP702, HSPA1A, HSPA1, HSX70
Target/Specificity This HSPA1A antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 574-600 amino acids from human HSPA1A.
Dilution WB~~1:100~2000
Format Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsHSPA1A Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms HSPA1, HSX70
Function In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage. In case of rotavirus A infection, serves as a post-attachment receptor for the virus to facilitate entry into the cell. Essential for STUB1-mediated ubiquitination and degradation of FOXP3 in regulatory T-cells (Treg) during inflammation (PubMed:23973223).
Cellular Location Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs
Tissue Location HSPA1B is testis-specific.
Research Areas
Citations (0)

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This intronless gene encodes a 70kDa heat shock protein which is a member of the heat shock protein 70 family. In conjuction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. It is also involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which encode similar proteins.


Wang, Y., et al. Clin. Chem. Lab. Med. 48(11):1657-1663(2010)
Eisenberg, D.P., et al. Surgery 148(2):325-334(2010)
Rusai, K., et al. Transplant. Proc. 42(6):2309-2311(2010)
Ebrahimi, M., et al. Mol. Vis. 16, 1680-1688 (2010) :
Lanneau, D., et al. ScientificWorldJournal 10, 1543-1552 (2010) :

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$ 295.00
$ 99.00
Cat# AM1877b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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