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ULK2 antibody ( Ascites)Mouse Monoclonal Antibody (Mab)
| Country | United States
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| Catalog # | Size | Availability | Price | |
| AM1884a | 0.1 ml 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
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ULK2 antibody ( Ascites) - Product info | |
| Application | WB
|
| Primary Accession | Q8IYT8 |
| Reactivity | Human |
| Concentration | Crude ascites |
| Isotype | IgM,K |
| Clone Names | 218CT21.2.6 |
| Calculated MW | 112694 Da |
ULK2 antibody ( Ascites) - Additional info | |
| Gene ID 9706 | |
| Other Names ULK2; KIAA0623; Serine/threonine-protein kinase ULK2; Unc-51-like kinase 2 | |
| Target/Specificity This ULK2 monoclonal antibody is generated from mouse immunized with ULK2 recombinant protein. | |
| Dilution WB~~1:100~3200 | |
| Format Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions ULK2 antibody ( Ascites) is for research use only and not for use in diagnostic or therapeutic procedures. | |
ULK2 antibody ( Ascites) - Protein Information | |
| Name ULK2 | |
| Synonyms KIAA0623 | |
| Function Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3- kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and a negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK, also acts as a negative regulator of AMPK through phosphorylation of the AMPK subunits PRKAA1, PRKAB2 and PRKAG1. May phosphorylate ATG13/KIAA0652, FRS2, FRS3 and RPTOR; however such data need additional evidences. Not involved in ammonia-induced autophagy or in autophagic response of cerebellar granule neurons (CGN) to low potassium concentration. Plays a role early in neuronal differentiation and is required for granule cell axon formation: may govern axon formation via Ras-like GTPase signaling and through regulation of the Rab5-mediated endocytic pathways within developing axons | |
| Cellular Location Cytoplasmic vesicle membrane; Peripheral membrane protein. Note=Localizes to pre-autophagosomal membrane | |
ULK2 antibody ( Ascites) - Related products
AM1884a: ULK2 antibody ( Ascites)
AP8105a: ULK2 Antibody (N-term)
AP8105b: ULK2 Antibody (C-term)
BP8105b: ULK2 Antibody (C-term) Blocking Peptide
ULK2 antibody ( Ascites) - Application data
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ULK2 antibody (Cat. #AM1884a) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the ULK2 antibody detected the ULK2 protein (arrow).
ULK2 antibody ( Ascites) - Research Areas
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BACKGROUND
This gene encodes a protein that is similar to a serine/threonine kinase in C. elegans which is involved in axonal elongation. The structure of this protein is similar to the C. elegans protein in that both proteins have an N-terminal kinase domain, a central proline/serine rich (PS) domain, and a C-terminal (C) domain. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq].
REFERENCES
Rose, J. Phd, et al. Mol. Med. (2010) In press : Jung, C.H., et al. Mol. Biol. Cell 20(7):1992-2003(2009) Stelzl, U., et al. Cell 122(6):957-968(2005) Tomoda, T., et al. Genes Dev. 18(5):541-558(2004) Yan, J., et al. Oncogene 18(43):5850-5859(1999)
