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>   home   >   Products   >   Primary Antibodies   >   ELAVL1 antibody (Ascites)   

ELAVL1 antibody (Ascites)

Mouse Monoclonal Antibody (Mab)

     
  • WB - ELAVL1 antibody (Ascites) AM1899a
    ELAVL1 antibody (Cat. #AM1899a) western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the ELAVL1 antibody detected the ELAVL1 protein (arrow).
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Product Information
ApplicationWB, E
Primary AccessionQ15717
Other AccessionNP_001410.2
ReactivityHuman
HostMouse
ClonalityMonoclonal
IsotypeIgG1,K
Clone Names224CT6.5.3
Calculated MW36092 Da
Additional Information
Gene ID1994
Other NamesELAV-like protein 1, Hu-antigen R, HuR, ELAVL1, HUR
Target/SpecificityThis ELAVL1 monoclonal antibody is generated from mouse immunized with ELAVL1 recombinant protein.
DilutionWB~~1:500~16000
FormatMouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.
Protein Information
NameELAVL1
SynonymsHUR
Function RNA-binding protein that binds to the 3'-UTR region of mRNAs and increases their stability. Involved in embryonic stem cells (ESCs) differentiation: preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), stabilizing them, promoting ESCs differentiation. Binds to poly-U elements and AU- rich elements (AREs) in the 3'-UTR of target mRNAs. Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA, and AUUUUUA motifs. Binds preferentially to the 5'-UUUU[AG]UUU-3' motif in vitro. With ZNF385A, binds the 3'-UTR of p53/TP53 mRNA to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind with ZNF385A the CCNB1 mRNA.
Cellular LocationCytoplasm. Nucleus. Note=Translocates into the cytoplasm following phosphorylation by MAPKAPK2
Tissue Location Ubiquitous.
Citations (0)

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Background

The protein encoded by this gene is a member of the ELAVL protein family. This encoded protein contains 3 RNA-binding domains and binds cis-acting AU-rich elements. It destabilizes mRNAs and thereby regulates gene expression.

References

Tholanikunnel, B.G., et al. J. Biol. Chem. 285(44):33816-33825(2010)
Drury, G.L., et al. J. Biol. Chem. 285(41):31130-31138(2010)
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Raspaglio, G., et al. Cancer Res. 70(14):5891-5900(2010)
Ahn, J., et al. Retrovirology 7, 40 (2010) :

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$ 265.00
Cat# AM1899a
Size:
Quantity:
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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