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ELAVL1 Antibody

Mouse Monoclonal Antibody (Mab)

Country
United States
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Ordering Information
Catalog # Size Availability Price  
AM1899B 400 µl In Stock $ 265.00 Add to cart
AM1899B-ev 80 µl In Stock $ 95.00 Add to cart
  • Specification
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ELAVL1 Antibody - Product info

ApplicationWB, IF
  • Applications Legend:
  • WB=Western Blotting
  • IP=Immunoprecipitation
  • IHC-P=Immunohistochemistry (Paraffin)
  • IF-IC=Immunofluorescence (Immunocytochemistry)
  • FC=Flow Cytometry
  • DB=Dot Blot
Primary AccessionQ15717
Other AccessionNP_001410.2
ReactivityHuman
IsotypeIgG1,K
Clone Names224CT6.5.3
Calculated MW36092 Da

ELAVL1 Antibody - Additional info

Gene ID 1994
Other Names
ELAVL1; HUR; ELAV-like protein 1; Hu-antigen R
Target/Specificity
This ELAVL1 monoclonal antibody is generated from mouse immunized with ELAVL1 recombinant protein.
Dilution
WB~~1:100~1000
IF~~1:10~50
Format
Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.
Storage
Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Precautions
ELAVL1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

ELAVL1 Antibody - Protein Information

Name ELAVL1
Synonyms HUR
Function
RNA-binding protein that binds to the 3'-UTR region of mRNAs and increases their stability. Involved in embryonic stem cells (ESCs) differentiation: preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), stabilizing them, promoting ESCs differentiation. Binds to poly-U elements and AU- rich elements (AREs) in the 3'-UTR of target mRNAs. Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA, and AUUUUUA motifs. Binds preferentially to the 5'-UUUU[AG]UUU-3' motif in vitro. With ZNF385A, binds the 3'-UTR of p53/TP53 mRNA to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind with ZNF385A the CCNB1 mRNA.
Cellular Location
Cytoplasm. Nucleus. Note=Translocates into the cytoplasm following phosphorylation by MAPKAPK2
Tissue Location
Ubiquitous.

ELAVL1 Antibody - Related products

AM1899a: ELAVL1 antibody (Ascites)

AP8963a: ELAVL1 Antibody

AT1891a: ELAVL1 Antibody (monoclonal) (M02)

ELAVL1 Antibody - Research Areas

Application data

  • WB - ELAVL1 Antibody AM1899B

    ELAVL1/MB10217 antibody (Cat. #AM1899b) western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the ELAVL1/MB10217 antibody detected the ELAVL1/MB10217 protein (arrow).

  • IF - ELAVL1 Antibody AM1899B

    Confocal immunofluorescent analysis of ELAVL1 Antibody (Cat#AM1899b) with NCI-H460 cell followed by Alexa Fluor 488-conjugated goat anti-mouse lgG (green). DAPI was used to stain the cell nuclear (blue).

  • WB - ELAVL1 Antibody AM1899B
  • IF - ELAVL1 Antibody AM1899B

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BACKGROUND

The protein encoded by this gene is a member of the ELAVL protein family. This encoded protein contains 3 RNA-binding domains and binds cis-acting AU-rich elements. It destabilizes mRNAs and thereby regulates gene expression.

REFERENCES

Tholanikunnel, B.G., et al. J. Biol. Chem. 285(44):33816-33825(2010)
Drury, G.L., et al. J. Biol. Chem. 285(41):31130-31138(2010)
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Raspaglio, G., et al. Cancer Res. 70(14):5891-5900(2010)
Ahn, J., et al. Retrovirology 7, 40 (2010) :