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Mouse Monoclonal Antibody (Mab)
United StatesOrdering Information
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|AM1899B||400 µl||In Stock||$ 265.00||DISCONTINUED INQUIRE CLICK INQUIRE Add to cart|
|AM1899B-ev||80 µl||In Stock||$ 95.00||DISCONTINED INQUIRE CLICK INQUIRE Add to cart|
- Citations : 0
ELAVL1 Antibody - Product Information
|Application ||WB, IF|
|Calculated MW||36092 Da Da|
ELAVL1 Antibody - Additional Information
|Gene ID 1994|
ELAV-like protein 1, Hu-antigen R, HuR, ELAVL1, HUR
This ELAVL1 monoclonal antibody is generated from mouse immunized with ELAVL1 recombinant protein.
Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.
Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
ELAVL1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
ELAVL1 Antibody - Protein Information
RNA-binding protein that binds to the 3'-UTR region of mRNAs and increases their stability. Involved in embryonic stem cells (ESCs) differentiation: preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), stabilizing them, promoting ESCs differentiation. Binds to poly-U elements and AU- rich elements (AREs) in the 3'-UTR of target mRNAs. Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA, and AUUUUUA motifs. Binds preferentially to the 5'-UUUU[AG]UUU-3' motif in vitro. With ZNF385A, binds the 3'-UTR of p53/TP53 mRNA to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind with ZNF385A the CCNB1 mRNA.
Cytoplasm. Nucleus. Note=Translocates into the cytoplasm following phosphorylation by MAPKAPK2
ELAVL1 Antibody - Related Products
ELAVL1 Antibody - Research Areas
ELAVL1/MB10217 antibody (Cat. #AM1899b) western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the ELAVL1/MB10217 antibody detected the ELAVL1/MB10217 protein (arrow).
Confocal immunofluorescent analysis of ELAVL1 Antibody (Cat#AM1899b) with NCI-H460 cell followed by Alexa Fluor 488-conjugated goat anti-mouse lgG (green). DAPI was used to stain the cell nuclear (blue).
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of the ELAVL protein family. This encoded protein contains 3 RNA-binding domains and binds cis-acting AU-rich elements. It destabilizes mRNAs and thereby regulates gene expression.
Tholanikunnel, B.G., et al. J. Biol. Chem. 285(44):33816-33825(2010)
Drury, G.L., et al. J. Biol. Chem. 285(41):31130-31138(2010)
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Raspaglio, G., et al. Cancer Res. 70(14):5891-5900(2010)
Ahn, J., et al. Retrovirology 7, 40 (2010) :