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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   MYO1C Antibody (ascites)   

MYO1C Antibody (ascites)

Mouse Monoclonal Antibody (Mab)

  • WB - MYO1C Antibody (ascites) AM1905a
    MYO1C (Cat. #AM1905a) western blot analysis in MDA-MB435 cell line lysates (35μg/lane).This demonstrates the MYO1C antibody detected the MYO1C protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O00159
Other Accession Q27966, NP_203693.3, NP_001074248.1
Reactivity Human
Predicted Bovine
Host Mouse
Clonality Monoclonal
Isotype IgM,k
Clone Names 221CT4.7.2.4
Calculated MW 121682 Da
Additional Information
Gene ID 4641
Other Names Unconventional myosin-Ic, Myosin I beta, MMI-beta, MMIb, MYO1C
Target/Specificity This MYO1C monoclonal antibody is generated from mouse immunized with MYO1C recombinant protein.
Dilution WB~~1:100~500
Format Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMYO1C Antibody (ascites) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MYO1C
Function Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. Involved in glucose transporter recycling in response to insulin by regulating movement of intracellular GLUT4-containing vesicles to the plasma membrane. Component of the hair cell's (the sensory cells of the inner ear) adaptation-motor complex. Acts as a mediator of adaptation of mechanoelectrical transduction in stereocilia of vestibular hair cells. Binds phosphoinositides and links the actin cytoskeleton to cellular membranes.
Cellular Location Isoform 1: Cytoplasm. Nucleus. Note=Colocalizes with RNA polymerase II. Absent from nucleoli and does not colocalize with RNA polymerase I. Translocates to nuclear speckles upon exposure to inhibitors of RNA polymerase II transcription Isoform 3: Nucleus, nucleoplasm. Nucleus, nucleolus. Nucleus, nuclear pore complex. Note=Colocalizes with RNA polymerase II in the nucleus. Colocalizes with RNA polymerase I in nucleoli (By similarity). In the nucleolus, is localized predominantly in dense fibrillar component (DFC) and in granular component (GC). Accumulates strongly in DFC and GC during activation of transcription. Colocalizes with transcription sites Colocalizes in the granular cortex at the periphery of the nucleolus with RPS6. Colocalizes in nucleoplasm with RPS6 and actin that are in contact with RNP particles. Colocalizes with RPS6 at the nuclear pore level.
Research Areas
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This gene encodes a member of the unconventional myosin protein family, which are actin-based molecular motors. The protein is found in the cytoplasm, and one isoform with a unique N-terminus is also found in the nucleus. The nuclear isoform associates with RNA polymerase I and II and functions in transcription initiation. The mouse ortholog of this protein also functions in intracellular vesicle transport to the plasma membrane. Multiple transcript variants encoding different isoforms have been found for this gene. The related gene myosin IE has been referred to as myosin IC in the literature, but it is a distinct locus on chromosome 19. [provided by RefSeq].


Obrdlik, A., et al. FASEB J. 24(1):146-157(2010)
Zadro, C., et al. Biochim. Biophys. Acta 1792(1):27-32(2009)
Laakso, J.M., et al. Science 321(5885):133-136(2008)
Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
Olsen, J.V., et al. Cell 127(3):635-648(2006)

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$ 295.00
Cat# AM1905a
(40 western blots)
Availability: In Stock
Bulk Size
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