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GNPDA1 Antibody

Mouse Monoclonal Antibody (Mab)

     
  • WB - GNPDA1 Antibody AM1910b
    GNPDA1 (Cat. #AM1910b) western blot analysis in mouse kidney tissue lysates (35μg/lane).This demonstrates the GNPDA1 antibody detected the GNPDA1 protein (arrow).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession P46926
Other Accession NP_005462.1
Reactivity Mouse
Host Mouse
Clonality Monoclonal
Isotype IgG1,k
Clone/Animal Names 237CT2.5.2
Calculated MW 32669 Da
Additional Information
Gene ID 10007
Other Names Glucosamine-6-phosphate isomerase 1, Glucosamine-6-phosphate deaminase 1, GNPDA 1, GlcN6P deaminase 1, Oscillin, GNPDA1, GNPI, HLN, KIAA0060
Target/Specificity This GNPDA1 monoclonal antibody is generated from mouse immunized with GNPDA1 recombinant protein.
Dilution WB~~1:100~1000
Format Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGNPDA1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GNPDA1 {ECO:0000303|PubMed:26887390, ECO:0000312|HGNC:HGNC:4417}
Function Catalyzes the reversible conversion of alpha-D-glucosamine 6- phosphate (GlcN-6P) into beta-D-fructose 6-phosphate (Fru-6P) and ammonium ion, a regulatory reaction step in de novo uridine diphosphate-N-acetyl-alpha-D-glucosamine (UDP-GlcNAc) biosynthesis via hexosamine pathway. Deamination is coupled to aldo-keto isomerization mediating the metabolic flux from UDP-GlcNAc toward Fru-6P. At high ammonium level can drive amination and isomerization of Fru-6P toward hexosamines and UDP-GlcNAc synthesis (PubMed:21807125, PubMed:26887390). Has a role in fine tuning the metabolic fluctuations of cytosolic UDP-GlcNAc and their effects on hyaluronan synthesis that occur during tissue remodeling (PubMed:26887390). Seems to trigger calcium oscillations in mammalian eggs. These oscillations serve as the essential trigger for egg activation and early development of the embryo (By similarity).
Cellular Location Cytoplasm.
Research Areas
Citations (0)
citation

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Background

Glucosamine-6-phosphate deaminase (EC 3.5.99.6) is an allosteric enzyme that catalyzes the reversible conversion of D-glucosamine-6-phosphate into D-fructose-6-phosphate and ammonium (Arreola et al., 2003 [PubMed 12965206]).

References

Lamesch, P., et al. Genomics 89(3):307-315(2007) Arreola, R., et al. FEBS Lett. 551 (1-3), 63-70 (2003) : Zhang, J., et al. J. Cell. Biochem. 88(5):932-940(2003) Nakamura, Y., et al. Genomics 68(2):179-186(2000) Shevchenko, V., et al. Gene 216(1):31-38(1998)

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$ 182.50
$ 70.00
Cat# AM1910b
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