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THOC1 Antibody (N-term) (ascites)

Mouse Monoclonal Antibody (Mab)

  • WB - THOC1 Antibody (N-term) (ascites) AM1950A
    THOC1 Antibody (N-term) (Cat. #AM1950a) western blot analysis in T47D cell line lysates (35μg/lane).This demonstrates the THOC1 antibody detected the THOC1 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q96FV9
Other Accession Q8R3N6, NP_005122.2
Reactivity Human
Predicted Mouse
Host Mouse
Clonality Monoclonal
Isotype IgG3
Clone Names 301CT40.5.1
Calculated MW 75666 Da
Antigen Region 257-285 aa
Additional Information
Gene ID 9984
Other Names THO complex subunit 1, Tho1, Nuclear matrix protein p84, p84N5, hTREX84, THOC1, HPR1
Target/Specificity This THOC1 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 257-285 amino acids from the N-terminal region of human THOC1.
Dilution WB~~1:100~8000
Format Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsTHOC1 Antibody (N-term) (ascites) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name THOC1
Synonyms HPR1
Function Required for efficient export of polyadenylated RNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. Regulates transcriptional elongation of a subset of genes. Involved in genome stability by preventing co-transcriptional R-loop formation.
Cellular Location Isoform 1: Nucleus speckle. Nucleus, nucleoplasm. Nucleus matrix. Cytoplasm. Note=Can shuttle between the nucleus and cytoplasm. Nuclear localization is required for induction of apoptotic cell death. Translocates to the cytoplasm during the early phase of apoptosis execution
Tissue Location Ubiquitous. Expressed in various cancer cell lines. Expressed at very low levels in normal breast epithelial cells and highly expressed in breast tumors. Expression is strongly associated with an aggressive phenotype of breast tumors and expression correlates with tumor size and the metastatic state of the tumor progression.
Citations (0)

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HPR1 is part of the TREX (transcription/export) complex, which includes TEX1 (MIM 606929), THO2 (MIM 300395), ALY (MIM 604171), and UAP56 (MIM 142560).


Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Liu, Y., et al. Mol. Psychiatry (2010) In press :
Boyne, J.R., et al. PLoS Pathog. 4 (10), E1000194 (2008) :
Ferreira, M.A., et al. Nat. Genet. 40(9):1056-1058(2008)
Yang, J., et al. Ann. Clin. Lab. Sci. 38(2):105-112(2008)

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$ 295.00
Cat# AM1950A
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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