- Antibodies
- New
- Biological Process >
- Cellular Compartment >
- Disease >
- Molecular Function >
- Pathway Biocarta >
- Pathway KEGG >
- Pathway Panther >
- Tissue >
- Tag
- Peptides
- Biological Process >
- Cellular Compartment >
- Disease >
- Molecular Function >
- Pathway Biocarta >
- Pathway KEGG >
- Pathway Panther >
- Tissue >
- Amino Acids
- Tag
- Biological Process >
- Proteins
- RNAi
- FL cDNA Clones
- Cell/Tissues/Lysates
> home > Products > Antibodies > Biological Process > Cell Death > THOC1 Antibody (N-term) (ascites)
THOC1 Antibody (N-term) (ascites)Mouse Monoclonal Antibody (Mab)
| Country | United States
Ordering Information
Australia Austria Belgium Brazil Bulgaria Canada China Croatia Cyprus Czech Republic Denmark Estonia Finland France Germany Greece Hungary Iceland India Indonesia Ireland Israel Italy Japan Korea Latvia Lithuania Luxembourg Macedonia Malaysia Malta Netherlands Norway Pakistan Poland Portugal Romania Serbia Singapore Slovakia Slovenia Spain Sweden Switzerland Taiwan Turkey United Kingdom United States Vietnam Others 
|
|||
|---|---|---|---|---|
| Catalog # | Size | Availability | Price | |
| AM1950a | 0.1 ml 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
- Protocols
- Backgrounds
THOC1 Antibody (N-term) (ascites) - Product info | |
| Application | WB
|
| Primary Accession | Q96FV9 |
| Other Accession | NP_005122.2 |
| Reactivity | Human |
| Concentration | Crude ascites |
| Isotype | IgG3 |
| Clone Names | 301CT40.5.1 |
| Calculated MW | 75666 Da |
THOC1 Antibody (N-term) (ascites) - Additional info | |
| Gene ID 9984 | |
| Other Names THOC1; HPR1; THO complex subunit 1; Nuclear matrix protein p84; hTREX84 | |
| Target/Specificity This THOC1 monoclonal antibody is generated from mouse immunized with THOC1 recombinant protein. | |
| Dilution WB~~1:100~8000 | |
| Format Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions THOC1 Antibody (N-term) (ascites) is for research use only and not for use in diagnostic or therapeutic procedures. | |
THOC1 Antibody (N-term) (ascites) - Protein Information | |
| Name THOC1 | |
| Synonyms HPR1 | |
| Function Component of the THO subcomplex of the TREX complex. The TREX complex specifically associates with spliced mRNA and not with unspliced pre-mRNA. It is recruited to spliced mRNAs by a transcription-independent mechanism. Binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export. The recruitment occurs via an interaction between ALYREF/THOC4 and the cap-binding protein NCBP1. DDX39B functions as a bridge between ALYREF/THOC4 and the THO complex. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. The recruitment of the TREX complex to the intronless viral mRNA occurs via an interaction between KSHV ORF57 protein and ALYREF/THOC4 | |
| Cellular Location Isoform 1: Nucleus speckle. Nucleus, nucleoplasm. Nucleus matrix. Cytoplasm. Note=Can shuttle between the nucleus and cytoplasm. Nuclear localization is required for induction of apoptotic cell death. Translocates to the cytoplasm during the early phase of apoptosis execution | |
| Tissue Location Ubiquitous. Expressed in various cancer cell lines. Expressed at very low levels in normal breast epithelial cells and highly expressed in breast tumors. Expression is strongly associated with an aggressive phenotype of breast tumors and expression correlates with tumor size and the metastatic state of the tumor progression | |
THOC1 Antibody (N-term) (ascites) - Related products
AM1950a: THOC1 Antibody (N-term) (ascites)
THOC1 Antibody (N-term) (ascites) - Application data
-
THOC1 Antibody (N-term) (Cat. #AM1950a) western blot analysis in T47D cell line lysates (35ug/lane).This demonstrates the THOC1 antibody detected the THOC1 protein (arrow).
THOC1 Antibody (N-term) (ascites) - Research Areas
AntibodiesBiological ProcessCell DeathSignal TransductionMetabolic ProcessPrimary Metabolic ProcessCellular Metabolic ProcessCellular ProcessMacromolecule Metabolic ProcessCellular Macromolecule Metabolic ProcessInterspecies Interaction Between OrganismsDeathProgrammed Cell DeathApoptosisIntracellular TransportMulti-organism ProcessBiological RegulationNucleocytoplasmic TransportNuclear TransportEstablishment Of Localization In CellRegulation Of Biological ProcessReproductionCellular LocalizationReproductive ProcessInteraction With HostRegulation Of Cellular ProcessNitrogen Compound Metabolic ProcessPathway KEGGApoptosis
Abgent welcomes feedback from its customers.
If you have used an Abgent product and would like to share how it has performed, please click on the
"Submit Review" button and provide the requested information. Our staff will examine and post your
review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abgent.com.
Thank you for your support.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
HPR1 is part of the TREX (transcription/export) complex, which includes TEX1 (MIM 606929), THO2 (MIM 300395), ALY (MIM 604171), and UAP56 (MIM 142560).
REFERENCES
Davila, S., et al. Genes Immun. 11(3):232-238(2010) Liu, Y., et al. Mol. Psychiatry (2010) In press : Boyne, J.R., et al. PLoS Pathog. 4 (10), E1000194 (2008) : Ferreira, M.A., et al. Nat. Genet. 40(9):1056-1058(2008) Yang, J., et al. Ann. Clin. Lab. Sci. 38(2):105-112(2008)
