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ACTA1 AntibodyMouse Monoclonal Antibody (Mab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AM1965b | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
| AM1965b-ev20 | 20 ug 100 ul | In Stock | $ 95.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
- Protocols
- Backgrounds
ACTA1 Antibody - Product info | |
| Application | WB, IHC, FC
|
| Primary Accession | P68133 |
| Other Accession | NP_001091.1 |
| Reactivity | Human |
| Concentration | 0.25 mg/ml |
| Isotype | IgG1,k |
| Clone Names | 337CT30.10.1 |
| Calculated MW | 42051 Da |
ACTA1 Antibody - Additional info | |
| Gene ID 58 | |
| Other Names ACTA1; ACTA; Actin, alpha skeletal muscle; Alpha-actin-1 | |
| Target/Specificity This ACTA1 monoclonal antibody is generated from mouse immunized with ACTA1 recombinant protein. | |
| Dilution WB~~1:100~500 IHC~~1:10~50 FC~~1:10~50 | |
| Format Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions ACTA1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. | |
ACTA1 Antibody - Protein Information | |
| Name ACTA1 | |
| Synonyms ACTA | |
| Function Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells | |
| Cellular Location Cytoplasm, cytoskeleton. | |
ACTA1 Antibody - Related products
AM1965a: ACTA1 Antibody (Ascites)
AP14779b: ACTA1/?-actin Antibody (C-term)
AP17487b: ACTA1/?-actin Antibody (C-term)
ACTA1 Antibody - Application data
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ACTA1 Antibody(Cat. #AM1965b) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the ACTA1 antibody detected the ACTA1 protein (arrow).
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ACTA1 Antibody (Cat. #AM1965b)immunohistochemistry analysis in formalin fixed and paraffin embedded human colon carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of ACTA1 Antibody for immunohistochemistry. Clinical relevance has not been evaluated.
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ACTA1 Antibody (Cat. #AM1965b)immunohistochemistry analysis in formalin fixed and paraffin embedded human skeletal muscle followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of ACTA1 Antibody for immunohistochemistry. Clinical relevance has not been evaluated.
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ACTA1 Antibody (Cat. #AM1965b) flow cytometric analysis of A549 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
ACTA1 Antibody - Research Areas
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BACKGROUND
The product encoded by this gene belongs to the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. Alpha, beta and gamma actin isoforms have been identified, with alpha actins being a major constituent of the contractile apparatus, while beta and gamma actins are involved in the regulation of cell motility. This actin is an alpha actin that is found in skeletal muscle. Mutations in this gene cause nemaline myopathy type 3, congenital myopathy with excess of thin myofilaments, congenital myopathy with cores, and congenital myopathy with fiber-type disproportion, diseases that lead to muscle fiber defects.
REFERENCES
Kim, E.Y., et al. Am. J. Physiol. Renal Physiol. 299 (3), F594-F604 (2010) : Haigh, S.E., et al. Neuromuscul. Disord. 20(6):363-374(2010) Yu, G., et al. J Clin Neurosci 17(6):766-769(2010) Yu, C.H., et al. PLoS ONE 5 (7), E11878 (2010) : Licastro, F., et al. Curr. Pharm. Des. 16(7):783-788(2010)
