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Dicer1 Antibody (Ascites)

Mouse Monoclonal Antibody (Mab)

  • WB - Dicer1 Antibody (Ascites) AM1970a
    Dicer1 Antibody (Cat. #AM1970a) western blot analysis in HepG2 cell line lysates (35μg/lane).This demonstrates the Dicer1 antibody detected the Dicer1 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9UPY3
Other Accession Q8R418, Q6TV19, Q6TUI4, NP_803187.1, NP_085124.2
Reactivity Human
Predicted Bovine, Zebrafish, Mouse
Host Mouse
Clonality Monoclonal
Isotype IgG1
Clone Names 336CT7.4.2
Calculated MW 218682 Da
Antigen Region 879-908 aa
Additional Information
Gene ID 23405
Other Names Endoribonuclease Dicer, Helicase with RNase motif, Helicase MOI, DICER1, DICER, HERNA, KIAA0928
Target/Specificity This Dicer1 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 879-908 amino acids from human Dicer1.
Dilution WB~~1:500~2000
Format Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsDicer1 Antibody (Ascites) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms DICER, HERNA, KIAA0928
Function Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA- induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, also called RNA interference, controls the elimination of transcripts from mobile and repetitive DNA elements of the genome but also the degradation of exogenous RNA of viral origin for instance. The miRNA pathway on the other side is a mean to specifically regulate the expression of target genes.
Cellular Location Cytoplasm.
Citations (0)

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This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. Alternative splicing results in multiple transcript variants.


Abe, M., et al. FEBS Lett. 584(20):4313-4318(2010)
Lin, R.J., et al. Cancer Res. 70(20):7841-7850(2010)
Kim, J.S., et al. Mol. Carcinog. 49(10):913-921(2010)
Potenza, N., et al. FEBS Lett. 584(15):3452-3457(2010)
Sinkkonen, L., et al. PLoS ONE 5 (8), E12175 (2010) :

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$ 295.00
Cat# AM1970a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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