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TNINI3 Antibody (Ascites)
Mouse Monoclonal Antibody (Mab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P19429 |
| Other Accession | P02646, P08057, NP_000354.4, Q5PYI0 |
| Reactivity | Human |
| Predicted | Bovine, Horse, Rabbit |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgM |
| Clone/Animal Names | 358CT10.3.6 |
| Calculated MW | 24008 Da |
| Antigen Region | 52-79 aa |
| Gene ID | 7137 |
|---|---|
| Other Names | Troponin I, cardiac muscle, Cardiac troponin I, TNNI3, TNNC1 |
| Target/Specificity | This TNINI3 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 52-79 amino acids from human TNINI3. |
| Dilution | WB~~1:500~8000 |
| Format | Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | TNINI3 Antibody (Ascites) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TNNI3 |
|---|---|
| Synonyms | TNNC1 |
| Function | Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM).
References
Millat, G., et al. Clin. Chim. Acta 411 (23-24), 1983-1991 (2010) :
Murakami, C., et al. Leg Med (Tokyo) 12(6):280-283(2010)
Millat, G., et al. Eur J Med Genet 53(5):261-267(2010)
Di Chiara, A., et al. J Cardiovasc Med (Hagerstown) 11(8):587-592(2010)
Napan, S., et al. Coron. Artery Dis. 21(5):261-265(2010)
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