|Application ||WB, E|
|Calculated MW||36708 Da|
|Antigen Region||136-163 aa|
|Other Names||Polycomb complex protein BMI-1, Polycomb group RING finger protein 4, Bmi1, Bmi-1, Pcgf4|
|Target/Specificity||This Mouse Bmi1 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 136-163 amino acids from mouse Bmi1.|
|Format||Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Euglobin precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Mouse Bmi1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2 (By similarity).|
|Cellular Location||Nucleus. Cytoplasm.|
|Tissue Location||Detected in most organs with high expression levels in thymus, heart, brain and testis|
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Component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (By similarity). In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2.
Pereira, J.D., et al. Proc. Natl. Acad. Sci. U.S.A. 107(36):15957-15962(2010)
Chiba, T., et al. Hepatology 52(3):1111-1123(2010)
Maertens, G.N., et al. EMBO J. 29(15):2553-2565(2010)
Lee, K.S., et al. Oncogene 29(23):3349-3361(2010)
Schaller, M.A., et al. PLoS ONE 5 (8), E12172 (2010) :
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