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TLE1 Antibody (Center) (Ascites)

Mouse Monoclonal Antibody (Mab)

     
  • WB - TLE1 Antibody (Center) (Ascites) AM1982a
    TLE1 antibody (Center) (Cat. #AM1982a) western blot analysis in A549 cell line lysates (35μg/lane).This demonstrates the TLE1 antibody detected the TLE1 protein (arrow).
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q04724
Other Accession NP_005068.2
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG1
Clone Names 381CT18.5.1
Calculated MW 83201 Da
Antigen Region 199-228 aa
Additional Information
Gene ID 7088
Other Names Transducin-like enhancer protein 1, E(Sp1) homolog, Enhancer of split groucho-like protein 1, ESG1, TLE1
Target/Specificity This TLE1 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 199-228 amino acids from the Central region of human TLE1.
Dilution WB~~1:500~8000
Format Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsTLE1 Antibody (Center) (Ascites) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TLE1
Function Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG.
Cellular Location Nucleus. Note=Nuclear and chromatin-associated, depending on isoforms and phosphorylation status. Hyperphosphorylation decreases the affinity for nuclear components
Tissue Location In all tissues examined, mostly in brain, liver and muscle
Research Areas
Citations (0)

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Background

Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG.

References

Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Carvalho, L.R., et al. Mol. Endocrinol. 24(4):754-765(2010)
Ali, S.A., et al. Proc. Natl. Acad. Sci. U.S.A. 107(9):4165-4169(2010)
Jagdis, A., et al. Am. J. Surg. Pathol. 33(12):1743-1751(2009)
Buscarlet, M., et al. PLoS ONE 4 (12), E8107 (2009) :

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$ 295.00
Cat# AM1982a
Size:
Quantity:
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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