|Application ||WB, E|
|Calculated MW||47443 Da|
|Antigen Region||262-291 aa|
|Other Names||Brachyury protein, Protein T, T|
|Target/Specificity||This T antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 262-291 amino acids from human T.|
|Format||Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Euglobin precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||T Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in the transcriptional regulation of genes required for mesoderm formation and differentiation. Binds to a palindromic site (called T site) and activates gene transcription when bound to such a site.|
|Tissue Location||Detected in testis, but not in other, normal tissues. Detected in lung tumors (at protein level)|
firstname.lastname@example.org, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is an embryonic nuclear transcription factor that binds to a specific DNA element, the palindromic T-site. It binds through a region in its N-terminus, called the T-box, and effects transcription of genes required for mesoderm formation and differentiation. The protein is localized to notochord-derived cells.
Jambhekar, N.A., et al. Arch. Pathol. Lab. Med. 134(8):1181-1187(2010)
Docherty, S.J., et al. BMC Genet. 11, 61 (2010) :
Yang, X.R., et al. Nat. Genet. 41(11):1176-1178(2009)
Oakley, G.J., et al. Mod. Pathol. 21(12):1461-1469(2008)
Bondue, A., et al. Cell Stem Cell 3(1):69-84(2008)
If you have any additional inquiries please email technical services at email@example.com.