|Application ||WB, E|
|Other Accession||P63251, P63250, E1BNE9, NP_002230.1|
|Predicted||Bovine, Mouse, Rat|
|Calculated MW||56603 Da|
|Antigen Region||390-418 aa|
|Other Names||G protein-activated inward rectifier potassium channel 1, GIRK-1, Inward rectifier K(+) channel Kir31, Potassium channel, inwardly rectifying subfamily J member 3, KCNJ3, GIRK1|
|Target/Specificity||This KCNJ3 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 390-418 amino acids from the C-terminal region of human KCNJ3.|
|Format||Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||KCNJ3 Antibody (C-term)(Ascites) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This receptor plays a crucial role in regulating the heartbeat.|
|Cellular Location||Membrane; Multi-pass membrane protein.|
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Provided below are standard protocols that you may find useful for product applications.
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and plays an important role in regulating heartbeat. It associates with three other G-protein-activated potassium channels to form a heteromultimeric pore-forming complex.
Pinheiro, A.P., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B (5), 1070-1080 (2010) :
Wagner, V., et al. J. Cell. Biochem. 110(3):598-608(2010)
Holmegard, H.N., et al. Cardiology 115(3):176-181(2010)
Rusinova, R., et al. Pflugers Arch. 458(2):303-314(2009)
Robitaille, M., et al. Cell. Signal. 21(4):488-501(2009)
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