|Application ||WB, E|
|Calculated MW||47002 Da|
|Antigen Region||32-61 aa|
|Other Names||Gap junction gamma-2 protein, Connexin-466, Cx466, Connexin-47, Cx47, Gap junction alpha-12 protein, GJC2, GJA12|
|Target/Specificity||This GJC2 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 32-61 amino acids from the N-terminal region of human GJC2.|
|Format||Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Euglobin precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GJC2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a role in myelination in central and peripheral nervous systems.|
|Cellular Location||Cell membrane; Multi-pass membrane protein. Cell junction, gap junction|
|Tissue Location||Expressed in central nervous system, in sciatic nerve and sural nerve. Also detected in skeletal muscles|
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Provided below are standard protocols that you may find useful for product applications.
GJC2 is a gap junction protein. Gap junction proteins are members of a large family of homologous connexins and comprise 4 transmembrane, 2 extracellular, and 3 cytoplasmic domains. This gene plays a key role in central myelination and is involved in peripheral myelination in humans. Defects in this gene are the cause of autosomal recessive Pelizaeus-Merzbacher-like disease-1.
Ferrell, R.E., et al. Am. J. Hum. Genet. 86(6):943-948(2010)
Wang, J., et al. Brain Dev. 32(3):236-243(2010)
Ishikawa, T., et al. Rinsho Shinkeigaku 50(1):7-11(2010)
Ruf, N., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 150B (2), 226-232 (2009) :
Orthmann-Murphy, J.L., et al. Brain 132 (PT 2), 426-438 (2009) :
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