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PCBP2 Antibody(Ascites)Mouse Monoclonal Antibody (Mab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AM1999a | 0.1 ml 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
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PCBP2 Antibody(Ascites) - Product info | |
| Application | WB
|
| Primary Accession | Q15366 |
| Other Accession | NP_114366.1, NP_001122383.1 |
| Reactivity | Human |
| Concentration | Crude ascites |
| Isotype | IgG2b |
| Clone Names | 376CT13.1.2 |
| Calculated MW | 38580 Da |
PCBP2 Antibody(Ascites) - Additional info | |
| Gene ID 5094 | |
| Other Names PCBP2; Poly(rC)-binding protein 2; Alpha-CP2; Heterogeneous nuclear ribonucleoprotein E2 | |
| Target/Specificity Purified His-tagged PCBP2 protein(Fragment) was used to produced this monoclonal antibody. | |
| Dilution WB~~1:100~1600 | |
| Format Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions PCBP2 Antibody(Ascites) is for research use only and not for use in diagnostic or therapeutic procedures. | |
PCBP2 Antibody(Ascites) - Protein Information | |
| Name PCBP2 | |
| Function Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. Major cellular poly(rC)-binding protein. Binds also poly(rU). Negatively regulates cellular antiviral responses mediated by MAVS signaling. It acts as an adapter between MAVS and the E3 ubiquitin ligase ITCH, therefore triggering MAVS ubiquitinationa and degradation | |
| Cellular Location Nucleus. Cytoplasm. Note=Loosely bound in the nucleus. May shuttle between the nucleus and the cytoplasm | |
| Tissue Location Detected in all tissues examined. | |
PCBP2 Antibody(Ascites) - Related products
AM1999a: PCBP2 Antibody(Ascites)
AP12231b: PCBP2 Antibody (C-term)
RI13829: PCBP2 predesign siRNA
DC08914: Human PCBP2 cDNA Clone
LY12814a: PCBP2 Over-expression Lysate
LY13008a: PCBP2 Over-expression Lysate
PCBP2 Antibody(Ascites) - Application data
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PCBP2 Antibody (Cat. #AM1999a) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the PCBP2 antibody detected the PCBP2 protein (arrow).
PCBP2 Antibody(Ascites) - Research Areas
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BACKGROUND
The protein encoded by this gene appears to be multifunctional. Along with PCBP-1 and hnRNPK, it is one of the major cellular poly(rC)-binding proteins. The encoded protein contains three K-homologous (KH) domains which may be involved in RNA binding. Together with PCBP-1, this protein also functions as a translational coactivator of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES, promoting poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. This multiexon structural mRNA is thought to be retrotransposed to generate PCBP-1, an intronless gene with functions similar to that of PCBP2. This gene and PCBP-1 have paralogous genes (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. Thsi gene also has two processed pseudogenes (PCBP2P1 and PCBP2P2). Multiple transcript variants encoding different isoforms have been found for this gene.
REFERENCES
Eiring, A.M., et al. Cell 140(5):652-665(2010) Ogram, S.A., et al. Virology 397(1):14-22(2010) You, F., et al. Nat. Immunol. 10(12):1300-1308(2009) Fujimura, K., et al. Biochim. Biophys. Acta 1793(5):878-887(2009) Waggoner, S.A., et al. J. Biol. Chem. 284(14):9039-9049(2009)
