|Application ||WB, E|
|Other Accession||P11798, NP_037052.1|
|Calculated MW||54115 Da|
|Other Names||Calcium/calmodulin-dependent protein kinase type II subunit alpha, CaM kinase II subunit alpha, CaMK-II subunit alpha, Camk2a|
|Target/Specificity||Purified His-tagged Camk2a protein(Fragment) was used to produced this monoclonal antibody.|
|Format||Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||RAT Camk2a Antibody (ascites) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity (PubMed:15312654). Phosphorylates transcription factor FOXO3 on 'Ser-298'. Activates FOXO3 transcriptional activity (By similarity).|
|Cellular Location||Cell junction, synapse, presynaptic cell membrane. Cell junction, synapse. Note=Postsynaptic lipid rafts|
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CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity (By similarity).
Hund, T.J., et al. J. Clin. Invest. 120(10):3508-3519(2010) Xu, L., et al. Circ. Res. 107(3):398-407(2010) Guetg, N., et al. Proc. Natl. Acad. Sci. U.S.A. 107(31):13924-13929(2010) Blaich, A., et al. Proc. Natl. Acad. Sci. U.S.A. 107(22):10285-10289(2010) Jenkins, M.A., et al. J. Neurosci. 30(15):5125-5135(2010)
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