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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Mouse Irgm1 Antibody (C-term) (Ascites)   

Mouse Irgm1 Antibody (C-term) (Ascites)

Mouse Monoclonal Antibody (Mab)

     
  • WB - Mouse Irgm1 Antibody (C-term) (Ascites) AM2003a
    Mouse Irgm1 Antibody (Cat. #AM2003a) western blot analysis in mouse brain tissue lysates (35μg/lane).This demonstrates the IRGM1 antibody detected the IRGM1 protein (arrow).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q60766
Other Accession NP_032352.1
Reactivity Mouse
Host Mouse
Clonality Monoclonal
Isotype IgM
Clone Names 403CT8.5.5
Calculated MW 46552 Da
Additional Information
Gene ID 15944
Other Names Immunity-related GTPase family M protein 1, 365-, Interferon-inducible GTPase 3, Interferon-inducible protein 1, LPS-stimulated RAW 2647 macrophage protein 47, LRG-47, Irgm1, Ifi1, Iigp3, Irgm
Target/Specificity Purified His-tagged Mouse Irgm1 protein was used to produced this monoclonal antibody.
Dilution WB~~1:1000~16000
Format Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMouse Irgm1 Antibody (C-term) (Ascites) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Irgm1
Synonyms Ifi1, Iigp3, Irgm
Function Putative GTPase which is required for IFNG-mediated clearance of acute protozoan and bacterial infections. Functions in innate immune response probably through regulation of autophagy. May regulate proinflammatory cytokine production and prevent endotoxemia upon infection. Required for macrophage motility and possibly also for adhesion.
Cellular Location Golgi apparatus membrane. Cell membrane. Cytoplasmic vesicle, phagosome membrane. Cytoplasmic vesicle, autophagosome membrane. Lysosome membrane. Late endosome membrane Cell projection, phagocytic cup. Note=Behaves like an integral membrane protein. Recruited to the plasma membrane around forming phagocytic cups, it remains associated with maturing phagosomes Association with phagosomes is dependent on nucleotide-binding but is IFNG-independent. Preferentially associated with cis- and medial-Golgi. Also detected in late endosomes and lysosomes
Tissue Location Expressed in lung and primary macrophages.
Research Areas
Citations (0)

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Background

Putative GTPase which is required for IFNG-mediated clearance of acute protozoan and bacterial infections. Functions in innate immune response probably through regulation of autophagy. May regulate proinflammatory cytokine production and prevent endotoxemia upon infection. Required for macrophage motility and possibly also for adhesion.

References

Dhar, N., et al. Proc. Natl. Acad. Sci. U.S.A. 107(27):12275-12280(2010)
Xu, H., et al. FASEB J. 24(5):1583-1592(2010)
Henry, S.C., et al. J. Leukoc. Biol. 87(2):333-343(2010)
Zhao, Y.O., et al. PLoS ONE 5 (1), E8648 (2010) :
Tiwari, S., et al. Nat. Immunol. 10(8):907-917(2009)

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$ 295.00
Cat# AM2003a
Size:
Quantity:
(40 western blots)
Availability: In Stock
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