|Application ||WB, E|
|Calculated MW||46552 Da|
|Other Names||Immunity-related GTPase family M protein 1, 365-, Interferon-inducible GTPase 3, Interferon-inducible protein 1, LPS-stimulated RAW 2647 macrophage protein 47, LRG-47, Irgm1, Ifi1, Iigp3, Irgm|
|Target/Specificity||Purified His-tagged Mouse Irgm1 protein was used to produced this monoclonal antibody.|
|Format||Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Euglobin precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Mouse Irgm1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||Ifi1, Iigp3, Irgm|
|Function||Putative GTPase which is required for IFNG-mediated clearance of acute protozoan and bacterial infections. Functions in innate immune response probably through regulation of autophagy. May regulate proinflammatory cytokine production and prevent endotoxemia upon infection. Required for macrophage motility and possibly also for adhesion.|
|Cellular Location||Golgi apparatus membrane. Cell membrane. Cytoplasmic vesicle, phagosome membrane. Cytoplasmic vesicle, autophagosome membrane. Lysosome membrane. Late endosome membrane Cell projection, phagocytic cup. Note=Behaves like an integral membrane protein. Recruited to the plasma membrane around forming phagocytic cups, it remains associated with maturing phagosomes Association with phagosomes is dependent on nucleotide-binding but is IFNG-independent. Preferentially associated with cis- and medial-Golgi. Also detected in late endosomes and lysosomes|
|Tissue Location||Expressed in lung and primary macrophages.|
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Provided below are standard protocols that you may find useful for product applications.
Putative GTPase which is required for IFNG-mediated clearance of acute protozoan and bacterial infections. Functions in innate immune response probably through regulation of autophagy. May regulate proinflammatory cytokine production and prevent endotoxemia upon infection. Required for macrophage motility and possibly also for adhesion.
Dhar, N., et al. Proc. Natl. Acad. Sci. U.S.A. 107(27):12275-12280(2010)
Xu, H., et al. FASEB J. 24(5):1583-1592(2010)
Henry, S.C., et al. J. Leukoc. Biol. 87(2):333-343(2010)
Zhao, Y.O., et al. PLoS ONE 5 (1), E8648 (2010) :
Tiwari, S., et al. Nat. Immunol. 10(8):907-917(2009)
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