|Application ||WB, E|
|Other Accession||NP_001025459.1, NP_003114.1|
|Calculated MW||40322 Da|
|Antigen Region||32-60 aa|
|Other Names||Leukosialin, Galactoglycoprotein, GALGP, Leukocyte sialoglycoprotein, Sialophorin, CD43, SPN, CD43|
|Target/Specificity||This SPN/CD43 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 32-60 amino acids from the N-terminal region of human SPN/CD43.|
|Format||Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SPN/CD43 Antibody (N-term)(Ascites) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||One of the major glycoproteins of thymocytes and T lymphocytes. Plays a role in the physicochemical properties of the T-cell surface and in lectin binding. Presents carbohydrate ligands to selectins. Has an extended rodlike structure that could protrude above the glycocalyx of the cell and allow multiple glycan chains to be accessible for binding. Is a counter-receptor for SN/Siglec-1 (By similarity). During T-cell activation is actively removed from the T-cell-APC (antigen-presenting cell) contact site thus suggesting a negative regulatory role in adaptive immune response (By similarity).|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Cell surface of thymocytes, T-lymphocytes, neutrophils, plasma cells and myelomas|
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Provided below are standard protocols that you may find useful for product applications.
Sialophorin (leukosialin) is a major sialoglycoprotein on the surface of human T lymphocytes, monocytes, granulocytes, and some B lymphocytes, which appears to be important for immune function and may be part of a physiologic ligand-receptor complex involved in T-cell activation.
Urano-Tashiro, Y., et al. Infect. Immun. 76(10):4686-4691(2008)
Mambole, A., et al. J. Biol. Chem. 283(35):23627-23635(2008)
Seethala, R.R., et al. Appl. Immunohistochem. Mol. Morphol. 16(2):165-172(2008)
Khunkaewla, P., et al. Mol. Immunol. 45(6):1703-1711(2008)
Rawal, A., et al. Arch. Pathol. Lab. Med. 131(11):1673-1678(2007)
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