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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   LTB Antibody (C-term)(Ascites)   

LTB Antibody (C-term)(Ascites)

Mouse Monoclonal Antibody (Mab)

  • WB - LTB Antibody (C-term)(Ascites) AM2016a
    LTB Antibody (C-term) (Cat. #AM2016a) western blot analysis in HL-60 cell line lysates (35μg/lane).This demonstrates the LTB antibody detected the LTB protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q06643
Other Accession Q9TSV8, NP_033666.1, NP_002332.1
Reactivity Human
Predicted Pig
Host Mouse
Clonality Monoclonal
Isotype IgM
Clone Names 399CT9.3.4
Calculated MW 25390 Da
Antigen Region 199-227 aa
Additional Information
Gene ID 4050
Other Names Lymphotoxin-beta, LT-beta, Tumor necrosis factor C, TNF-C, Tumor necrosis factor ligand superfamily member 3, LTB, TNFC, TNFSF3
Target/Specificity This LTB antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 199-227 amino acids from the C-terminal region of human LTB.
Dilution WB~~1:2000~16000
Format Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsLTB Antibody (C-term)(Ascites) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name LTB
Synonyms TNFC, TNFSF3
Function Cytokine that binds to LTBR/TNFRSF3. May play a specific role in immune response regulation. Provides the membrane anchor for the attachment of the heterotrimeric complex to the cell surface. Isoform 2 is probably non-functional.
Cellular Location Membrane; Single-pass type II membrane protein
Tissue Location Spleen and thymus.
Research Areas
Citations (0)

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Lymphotoxin beta is a type II membrane protein of the TNF family. It anchors lymphotoxin-alpha to the cell surface through heterotrimer formation. The predominant form on the lymphocyte surface is the lymphotoxin-alpha 1/beta 2 complex (e.g. 1 molecule alpha/2 molecules beta) and this complex is the primary ligand for the lymphotoxin-beta receptor. The minor complex is lymphotoxin-alpha 2/beta 1. LTB is an inducer of the inflammatory response system and involved in normal development of lymphoid tissue. Lymphotoxin-beta isoform b is unable to complex with lymphotoxin-alpha suggesting a function for lymphotoxin-beta which is independent of lympyhotoxin-alpha. Alternative splicing results in multiple transcript variants encoding different isoforms.


Clancy, R.M., et al. Arthritis Rheum. 62(11):3415-3424(2010)
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Young, J., et al. Cytokine 51(1):78-86(2010)
McGeachie, M., et al. Circulation 120(24):2448-2454(2009)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)

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Cat# AM2016a
(40 western blots)
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