|Application ||WB, E|
|Other Accession||NP_001138734.1, NP_001138732.1|
|Calculated MW||69726 Da|
|Other Names||Nuclear receptor coactivator 4, NCoA-4, Androgen receptor coactivator 70 kDa protein, 70 kDa AR-activator, 70 kDa androgen receptor coactivator, Androgen receptor-associated protein of 70 kDa, Ret-activating protein ELE1, NCOA4, ARA70, ELE1, RFG|
|Target/Specificity||Purified His-tagged NCOA4 protein(Fragment) was used to produced this monoclonal antibody.|
|Format||Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||NCOA4 Antibody(Ascites) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||ARA70, ELE1, RFG|
|Function||Enhances the androgen receptor transcriptional activity in prostate cancer cells. Ligand-independent coactivator of the peroxisome proliferator-activated receptor (PPAR) gamma.|
|Tissue Location||Widely expressed. Also detected in adipose tissues and in different cell lines. Isoform Beta is only expressed in testis|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
This gene encodes an androgen receptor coactivator. The encoded protein interacts with the androgen receptor in a ligand-dependent manner to enhance its transcriptional activity. Chromosomal translocations between this gene and the ret tyrosine kinase gene, also located on chromosome 10, have been associated with papillary thyroid carcinoma. Alternatively spliced transcript variants have been described. Pseudogenes are present on chromosomes 4, 5, 10, and 14.
Sadow, P.M., et al. Endocr. Pathol. 21(2):73-79(2010)
Landa, I., et al. PLoS Genet. 5 (9), E1000637 (2009) :
Richardson, D.S., et al. Cancer Res. 69(11):4861-4869(2009)
Peng, Y., et al. Am. J. Pathol. 172(1):225-235(2008)
Bongarzone, I., et al. Genomics 42(2):252-259(1997)
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at firstname.lastname@example.org.