|Application ||WB, E|
|Other Accession||P60517, Q8MK68, Q9DCD6, Q9GJW7, NP_009209.1|
|Predicted||Bovine, Rabbit, Rat|
|Calculated MW||13918 Da|
|Other Names||Gamma-aminobutyric acid receptor-associated protein, GABA(A) receptor-associated protein, MM46, GABARAP, FLC3B|
|Target/Specificity||Purified His-tagged GABARAP protein(Fragment) was used to produced this monoclonal antibody.|
|Format||Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GABARAP Antibody(Ascites) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Ubiquitin-like modifier that plays a role in intracellular transport of GABA(A) receptors and its interaction with the cytoskeleton. Involved in apoptosis. Involved in autophagy. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation.|
|Cellular Location||Endomembrane system. Cytoplasm, cytoskeleton. Golgi apparatus membrane. Cytoplasmic vesicle, autophagosome Note=Largely associated with intracellular membrane structures including the Golgi apparatus and postsynaptic cisternae Colocalizes with microtubules (By similarity). Localizes also to discrete punctae along the ciliary axoneme (By similarity)|
|Tissue Location||Heart, brain, placenta, liver, skeletal muscle, kidney and pancreas.|
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Provided below are standard protocols that you may find useful for product applications.
Gamma-aminobutyric acid A receptors [GABA(A) receptors] are ligand-gated chloride channels that mediate inhibitory neurotransmission. This gene encodes GABA(A) receptor-associated protein, which is highly positively charged in its N-terminus and shares sequence similarity with light chain-3 of microtubule-associated proteins 1A and 1B. This protein clusters neurotransmitter receptors by mediating interaction with the cytoskeleton.
Garcia-Martin, E., et al. J. Neurol. (2010) In press :
Komoike, Y., et al. J. Hum. Genet. 55(3):155-162(2010)
Thielmann, Y., et al. Proteins 77(3):637-646(2009)
Schwarten, M., et al. Autophagy 5(5):690-698(2009)
Kirkin, V., et al. Mol. Cell 33(4):505-516(2009)
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