|Application ||WB, E|
|Other Accession||Q710C4, Q4R596, Q3MHL4, NP_000678.1, NP_001155238.1|
|Predicted||Bovine, Monkey, Pig|
|Calculated MW||47716 Da|
|Antigen Region||79-110 aa|
|Other Names||Adenosylhomocysteinase, AdoHcyase, S-adenosyl-L-homocysteine hydrolase, AHCY, SAHH|
|Target/Specificity||This AHCY antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 79-110 amino acids from human AHCY.|
|Format||Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||AHCY Antibody(Ascites) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Adenosylhomocysteine is a competitive inhibitor of S- adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine.|
|Cellular Location||Cytoplasm. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
firstname.lastname@example.org, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
S-adenosylhomocysteine hydrolase belongs to the adenosylhomocysteinase family. It catalyzes the reversible hydrolysis of S-adenosylhomocysteine (AdoHcy) to adenosine (Ado) and L-homocysteine (Hcy). Thus, it regulates the intracellular S-adenosylhomocysteine (SAH) concentration thought to be important for transmethylation reactions. Deficiency in this protein is one of the different causes of hypermethioninemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Gass, N., et al. J Affect Disord 126 (1-2), 134-139 (2010) :
Giusti, B., et al. Thromb. Haemost. 104(2):231-242(2010)
Levine, A.J., et al. Cancer Epidemiol. Biomarkers Prev. 19(7):1812-1821(2010)
Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at email@example.com.