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AHCY Antibody(Ascites)

Mouse Monoclonal Antibody (Mab)

     
  • WB - AHCY Antibody(Ascites) AM2030a
    AHCY Antibody (Cat. #AM2030a) western blot analysis in mouse liver tissue lysates (35μg/lane).This demonstrates the AHCY antibody detected the AHCY protein (arrow).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession P23526
Other Accession Q710C4, Q4R596, Q3MHL4, NP_000678.1, NP_001155238.1
Reactivity Human, Mouse
Predicted Bovine, Monkey, Pig
Host Mouse
Clonality Monoclonal
Isotype IgM
Clone/Animal Names 445CT13.3.3
Calculated MW 47716 Da
Antigen Region 79-110 aa
Additional Information
Gene ID 191
Other Names Adenosylhomocysteinase, AdoHcyase, S-adenosyl-L-homocysteine hydrolase, AHCY, SAHH
Target/Specificity This AHCY antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 79-110 amino acids from human AHCY.
Dilution WB~~1:1000~8000
Format Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsAHCY Antibody(Ascites) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name AHCY
Synonyms SAHH
Function Catalyzes the hydrolysis of S-adenosyl-L-homocysteine to form adenosine and homocysteine (PubMed:10933798). Binds copper ions (By similarity).
Cellular Location Cytoplasm. Melanosome. Nucleus. Endoplasmic reticulum. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV
Research Areas
Citations (0)
citation

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Background

S-adenosylhomocysteine hydrolase belongs to the adenosylhomocysteinase family. It catalyzes the reversible hydrolysis of S-adenosylhomocysteine (AdoHcy) to adenosine (Ado) and L-homocysteine (Hcy). Thus, it regulates the intracellular S-adenosylhomocysteine (SAH) concentration thought to be important for transmethylation reactions. Deficiency in this protein is one of the different causes of hypermethioninemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

References

Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Gass, N., et al. J Affect Disord 126 (1-2), 134-139 (2010) :
Giusti, B., et al. Thromb. Haemost. 104(2):231-242(2010)
Levine, A.J., et al. Cancer Epidemiol. Biomarkers Prev. 19(7):1812-1821(2010)
Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :

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$ 182.50
Cat# AM2030a
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