|Application ||WB, E|
|Calculated MW||50477 Da|
|Other Names||Sprouty-related, EVH1 domain-containing protein 1, Spred-1, hSpred1, SPRED1|
|Target/Specificity||Purified His-tagged SPRED1 protein(Fragment) was used to produced this monoclonal antibody.|
|Format||Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SPRED1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Tyrosine kinase substrate that inhibits growth-factor- mediated activation of MAP kinase. Negatively regulates hematopoiesis of bone marrow (By similarity).|
|Cellular Location||Cell membrane; Peripheral membrane protein Membrane, caveola; Peripheral membrane protein. Nucleus. Note=Localized in cholesterol-rich membrane raft/caveola fractions|
|Tissue Location||Weakly expressed in embryonic cell line HEK293.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of the Sprouty family of proteins and is phosphorylated by tyrosine kinase in response to several growth factors. The encoded protein can act as a homodimer or as a heterodimer with SPRED2 to regulate activation of the MAP kinase cascade. Defects in this gene are a cause of neurofibromatosis type 1-like syndrome (NFLS). [provided by RefSeq].
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Batz, C., et al. Blood 115(12):2557-2558(2010)
Messiaen, L., et al. JAMA 302(19):2111-2118(2009)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Spurlock, G., et al. J. Med. Genet. 46(7):431-437(2009)
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