|Application ||WB, E|
|Calculated MW||50477 Da|
|Other Names||Sprouty-related, EVH1 domain-containing protein 1, Spred-1, hSpred1, SPRED1|
|Target/Specificity||Purified His-tagged SPRED1 protein(Fragment) was used to produced this monoclonal antibody.|
|Format||Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SPRED1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Tyrosine kinase substrate that inhibits growth-factor- mediated activation of MAP kinase. Negatively regulates hematopoiesis of bone marrow (By similarity).|
|Cellular Location||Cell membrane; Peripheral membrane protein Membrane, caveola; Peripheral membrane protein. Nucleus. Note=Localized in cholesterol-rich membrane raft/caveola fractions|
|Tissue Location||Weakly expressed in embryonic cell line HEK293.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
firstname.lastname@example.org, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of the Sprouty family of proteins and is phosphorylated by tyrosine kinase in response to several growth factors. The encoded protein can act as a homodimer or as a heterodimer with SPRED2 to regulate activation of the MAP kinase cascade. Defects in this gene are a cause of neurofibromatosis type 1-like syndrome (NFLS). [provided by RefSeq].
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Batz, C., et al. Blood 115(12):2557-2558(2010)
Messiaen, L., et al. JAMA 302(19):2111-2118(2009)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Spurlock, G., et al. J. Med. Genet. 46(7):431-437(2009)
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at email@example.com.