|Application ||WB, E|
|Other Accession||O35789, Q9CW73, NP_061114.2|
|Calculated MW||38256 Da|
|Antigen Region||132-160 aa|
|Other Names||Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1, Beta-1, 3-glucuronyltransferase 1, Glucuronosyltransferase P, GlcAT-P, UDP-GlcUA:glycoprotein beta-1, 3-glucuronyltransferase, GlcUAT-P, B3GAT1, GLCATP|
|Target/Specificity||This B3GAT1 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 132-160 amino acids from human B3GAT1.|
|Format||Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Euglobin precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||B3GAT1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on glycoproteins. Can also play a role in glycosaminoglycan biosynthesis. Substrates include asialo- orosomucoid (ASOR), asialo-fetuin, and asialo-neural cell adhesion molecule. Requires sphingomyelin for activity: stearoyl- sphingomyelin was the most effective, followed by palmitoyl- sphingomyelin and lignoceroyl-sphingomyelin. Activity was demonstrated only for sphingomyelin with a saturated fatty acid and not for that with an unsaturated fatty acid, regardless of the length of the acyl group (By similarity).|
|Cellular Location||Golgi apparatus membrane; Single-pass type II membrane protein|
|Tissue Location||Mainly expressed in the brain.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of the glucuronyltransferase gene family. These enzymes exhibit strict acceptor specificity, recognizing nonreducing terminal sugars and their anomeric linkages. This gene product functions as the key enzyme in a glucuronyl transfer reaction during the biosynthesis of the carbohydrate epitope HNK-1 (human natural killer-1, also known as CD57 and LEU7). Alternate transcriptional splice variants have been characterized.
Akagi, J., et al. Int. J. Clin. Oncol. 15(2):145-152(2010)
Petrovas, C., et al. J. Immunol. 183(2):1120-1132(2009)
Saito, A., et al. J. Hum. Genet. 54(6):317-323(2009)
Chong, L.K., et al. Eur. J. Immunol. 38(4):995-1000(2008)
Casado, J.G., et al. Tumour Biol. 29(5):304-310(2008)
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