|Application ||WB, E|
|Calculated MW||29089 Da|
|Antigen Region||60-88 aa|
|Other Names||Low affinity immunoglobulin gamma Fc region receptor III-A, CD16a antigen, Fc-gamma RIII-alpha, Fc-gamma RIII, Fc-gamma RIIIa, FcRIII, FcRIIIa, FcR-10, IgG Fc receptor III-2, CD16a, FCGR3A, CD16A, FCG3, FCGR3, IGFR3|
|Target/Specificity||This FCGR3A antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 60-88 amino acids from human FCGR3A.|
|Format||Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||FCGR3A Antibody (Ascites) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||CD16A, FCG3, FCGR3, IGFR3|
|Function||Receptor for the Fc region of IgG. Binds complexed or aggregated IgG and also monomeric IgG. Mediates antibody-dependent cellular cytotoxicity (ADCC) and other antibody-dependent responses, such as phagocytosis.|
|Cellular Location||Cell membrane; Single-pass type I membrane protein. Secreted. Note=Exists also as a soluble receptor|
|Tissue Location||Expressed on natural killer cells, macrophages, subpopulation of T-cells, immature thymocytes and placental trophoblasts|
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This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other other antibody-dependent responses. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Dornan, D., et al. Blood 116(20):4212-4222(2010)
Li, S.C., et al. Am. J. Hematol. 85(10):810-812(2010)
Iwasaki, M., et al. Breast Cancer Res. Treat. (2010) In press :
Qu, Y.H., et al. Zhongguo Shi Yan Xue Ye Xue Za Zhi 18(4):959-962(2010)
Sfar, I., et al. Arch Inst Pasteur Tunis 86 (1-4), 51-62 (2009) :
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