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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   APOA1 Antibody (N-term)   

APOA1 Antibody (N-term)

Mouse Monoclonal Antibody (Mab)

  • WB - APOA1 Antibody (N-term) AM2045b
    APOA1 Antibody (N-term) (Cat. #AM2045b) western blot analysis in mouse brain tissue lysates (35μg/lane).This demonstrates the APOA1 antibody detected the APOA1 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P02647
Other Accession NP_000030.1
Reactivity Human, Mouse
Host Mouse
Clonality Monoclonal
Isotype IgG1
Clone Names 464CT10.4.4
Calculated MW 30778 Da
Antigen Region 10-37 aa
Additional Information
Gene ID 335
Other Names Apolipoprotein A-I, Apo-AI, ApoA-I, Apolipoprotein A1, Proapolipoprotein A-I, ProapoA-I, Truncated apolipoprotein A-I, Apolipoprotein A-I(1-242), APOA1
Target/Specificity This APOA1 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 10-37 amino acids from the N-terminal region of human APOA1.
Dilution WB~~1:100~250
Format Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsAPOA1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name APOA1
Function Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility.
Cellular Location Secreted.
Tissue Location Major protein of plasma HDL, also found in chylomicrons. Synthesized in the liver and small intestine. The oxidized form at Met-110 and Met-136 is increased in individuals with increased risk for coronary artery disease, such as in carrier of the eNOSa/b genotype and exposure to cigarette smoking It is also present in increased levels in aortic lesions relative to native ApoA-I and increased levels are seen with increasing severity of disease.
Research Areas
Citations (0)

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This gene encodes apolipoprotein A-I, which is the major protein component of high density lipoprotein (HDL) in plasma. The protein promotes cholesterol efflux from tissues to the liver for excretion, and it is a cofactor for lecithin cholesterolacyltransferase (LCAT) which is responsible for the formation of most plasma cholesteryl esters. This gene is closely linked with two other apolipoprotein genes on chromosome 11. Defects in this gene are associated with HDL deficiencies, including Tangier disease, and with systemic non-neuropathic amyloidosis.


Clemente-Postigo, M., et al. Clin. Biochem. 43 (16-17), 1300-1304 (2010) :
Romero, R., et al. Am. J. Obstet. Gynecol. 203 (4), 361 (2010) :
Dawar, R., et al. Am. J. Clin. Pathol. 134(2):249-255(2010)
Mattei, J., et al. Nutr Metab Cardiovasc Dis (2010) In press :
Bencharif, K., et al. Lipids Health Dis 9, 75 (2010) :

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Cat# AM2045b
(40 western blots)
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