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USP8 Antibody (C-term C1072) (Ascites)Mouse Monoclonal Antibody (Mab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AM2056a | 0.1 ml 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
- Protocols
- Backgrounds
USP8 Antibody (C-term C1072) (Ascites) - Product info | |
| Application | WB
|
| Primary Accession | P40818 |
| Other Accession | NP_001122082.1 |
| Reactivity | Human |
| Concentration | Crude ascites |
| Isotype | IgG1 |
| Clone Names | 460CT35.1.6 |
| Calculated MW | 127523 Da |
USP8 Antibody (C-term C1072) (Ascites) - Additional info | |
| Gene ID 9101 | |
| Other Names USP8; KIAA0055; UBPY; Ubiquitin carboxyl-terminal hydrolase 8; Deubiquitinating enzyme 8; Ubiquitin isopeptidase Y; Ubiquitin thioesterase 8; Ubiquitin-specific-processing protease 8 | |
| Target/Specificity This USP8 Monoclonal antibody is generated from mouses immunized with a KLH conjugated synthetic peptide selected from the C-term region of human USP8. | |
| Dilution WB~~1:500~4000 | |
| Format Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions USP8 Antibody (C-term C1072) (Ascites) is for research use only and not for use in diagnostic or therapeutic procedures. | |
USP8 Antibody (C-term C1072) (Ascites) - Protein Information | |
| Name USP8 | |
| Synonyms KIAA0055, UBPY | |
| Function Hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation. Converts both 'Lys-48' an 'Lys-63'-linked ubiquitin chains. Catalytic activity is enhanced in the M phase. Involved in cell proliferation Required to enter into S phase in response to serum stimulation May regulate T-cell anergy mediated by RNF128 via the formation of a complex containing RNF128 and OTUB1. Probably regulates the stability of STAM2 and RASGRF1. Regulates endosomal ubiquitin dynamics, cargo sorting, membrane traffic at early endosomes, and maintenance of ESCRT-0 stability. The level of protein ubiquitination on endosomes is essential for maintaining the morphology of the organelle. Deubiquitinates EPS15 and controles tyrosine kinase stability. Removes conjugated ubiquitin from EGFR thus regulating EGFR degradation and downstream MAPK signaling Involved in acrosome biogenesis through interaction with the spermatid ESCRT-0 complex and microtubules. Deubiquitinates BIRC6/bruce and KIF23/MKLP1 | |
| Cellular Location Cytoplasm. Nucleus (By similarity). Endosome membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein | |
USP8 Antibody (C-term C1072) (Ascites) - Related products
AM2056a: USP8 Antibody (C-term C1072) (Ascites)
AP2137a: USP8 Antibody (N-term)
AP2137b: USP8 (UBPY) Antibody (C-term)
AP2138b: USP8 (UBPY) Antibody (C-term)
BP2137a: USP8 Antibody (N-term) Blocking Peptide
USP8 Antibody (C-term C1072) (Ascites) - Application data
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USP8 Antibody (C1072) (Cat. #AM2056a) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the USP8 antibody detected the USP8 protein (arrow).
USP8 Antibody (C-term C1072) (Ascites) - Research Areas
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BACKGROUND
Hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation. Converts both 'Lys-48' an 'Lys-63'-linked ubiquitin chains. Catalytic activity is enhanced in the M phase. Involved in cell proliferation. Required to enter into S phase in response to serum stimulation. May regulate T-cell anergy mediated by RNF128 via the formation of a complex containing RNF128 and OTUB1. Probably regulates the stability of STAM2 and RASGRF1. Regulates endosomal ubiquitin dynamics, cargo sorting, membrane traffic at early endosomes, and maintenance of ESCRT-0 stability. The level of protein ubiquitination on endosomes is essential for maintaining the morphology of the organelle. Deubiquitinates EPS15 and controles tyrosine kinase stability. Removes conjugated ubiquitin from EGFR thus regulating EGFR degradation and downstream MAPK signaling. Involved in acrosome biogenesis through interaction with the spermatid ESCRT-0 complex and microtubules.
REFERENCES
Hasdemir, B., et al. J. Biol. Chem. 284(41):28453-28466(2009) Row, P.E., et al. J. Biol. Chem. 282(42):30929-30937(2007) Alwan, H.A., et al. J. Biol. Chem. 282(3):1658-1669(2007) Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) : Avvakumov, G.V., et al. J. Biol. Chem. 281(49):38061-38070(2006)
