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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   MAP3K12 Antibody (Ascites)   

MAP3K12 Antibody (Ascites)

Mouse Monoclonal Antibody (Mab)

  • WB - MAP3K12 Antibody (Ascites) AM2057a
    MAP3K12 Antibody (Cat. #AM2057a) western blot analysis in mouse brain tissue lysates (35μg/lane).This demonstrates the MAP3K12 antibody detected the MAP3K12 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q12852
Other Accession NP_001180440.1
Reactivity Human, Mouse
Host Mouse
Clonality Monoclonal
Isotype IgG1
Clone Names 473CT23.12.5
Calculated MW 93219 Da
Antigen Region 828-859 aa
Additional Information
Gene ID 7786
Other Names Mitogen-activated protein kinase kinase kinase 12, Dual leucine zipper bearing kinase, DLK, Leucine-zipper protein kinase, ZPK, MAPK-upstream kinase, MUK, Mixed lineage kinase, MAP3K12, ZPK
Target/Specificity This MAP3K12 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 828-859 amino acids from human MAP3K12.
Dilution WB~~1:800
Format Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMAP3K12 Antibody (Ascites) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MAP3K12
Synonyms ZPK
Function May be an activator of the JNK/SAPK pathway. Phosphorylates beta-casein, histone 1 and myelin basic protein in vitro.
Cellular Location Cytoplasm. Membrane; Peripheral membrane protein
Tissue Location Highly expressed in brain and kidney.
Research Areas
Citations (0)

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This gene encodes a member of the serine/threonine protein kinase family. This kinase contains a leucine-zipper domain and is predominately expressed in neuronal cells. The phosphorylation state of this kinase in synaptic terminals was shown to be regulated by membrane depolarization via calcineurin. This kinase forms heterodimers with leucine zipper containing transcription factors, such as cAMP responsive element binding protein (CREB) and MYC, and thus may play a regulatory role in PKA or retinoic acid induced neuronal differentiation. Alternatively spliced transcript variants encoding different proteins have been described.[provided by RefSeq].


Clague, J., et al. Mol. Carcinog. 49(2):183-189(2010)
Robitaille, H., et al. J. Invest. Dermatol. 130(1):74-85(2010)
Landa, I., et al. PLoS Genet. 5 (9), E1000637 (2009) :
Daviau, A., et al. Cell. Signal. 21(4):577-587(2009)
Mukhopadhyay, R., et al. Mol. Cell 32(3):371-382(2008)

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$ 295.00
Cat# AM2057a
(40 western blots)
Availability: In Stock
Bulk Size
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