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NOTCH3 Antibody (C-term Q2306)Mouse Monoclonal Antibody (Mab)

Country
United States
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Ordering Information
Catalog # Size Availability Price  
AM2059b 400 µl In Stock $ 265.00 Add to cart
AM2059b-ev 80 µl In Stock $ 95.00 Add to cart
  • Specification
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NOTCH3 Antibody (C-term Q2306) - Product info

ApplicationWB
  • Applications Legend:
  • WB=Western Blotting
  • IP=Immunoprecipitation
  • IHC-P=Immunohistochemistry (Paraffin)
  • IF-IC=Immunofluorescence (Immunocytochemistry)
  • FC=Flow Cytometry
  • DB=Dot Blot
Primary AccessionQ9UM47
Other AccessionNP_000426.2
ReactivityHuman
IsotypeIgG1
Clone Names487CT6.9.2
Calculated MW243631 Da

NOTCH3 Antibody (C-term Q2306) - Additional info

Gene ID 4854
Other Names
NOTCH3; Neurogenic locus notch homolog protein 3; Notch 3 extracellular truncation; Notch 3 intracellular domain
Target/Specificity
This NOTCH3 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 2291-2321 amino acids from the C-terminal region of human NOTCH3.
Dilution
WB~~1:100~250
Format
Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.
Storage
Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Precautions
NOTCH3 Antibody (C-term Q2306) is for research use only and not for use in diagnostic or therapeutic procedures.

NOTCH3 Antibody (C-term Q2306) - Protein Information

Name NOTCH3
Function
Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity).
Cellular Location
Cell membrane; Single-pass type I membrane protein
Tissue Location
Ubiquitously expressed in fetal and adult tissues

NOTCH3 Antibody (C-term Q2306) - Related products

AM2059a: NOTCH3 Antibody (C-term Q2306) (Ascites)

AP6220a: NOTCH3 Antibody (C-term)

BP6220a: NOTCH3 Antibody (C-term) Blocking Peptide

NOTCH3 Antibody (C-term Q2306) - Application data

  • NOTCH3 Antibody (Q2306) (Cat. #AM2059b) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the NOTCH3 antibody detected the NOTCH3 protein (arrow).

NOTCH3 Antibody (C-term Q2306) - Research Areas

AntibodiesGene OntologyBiological ProcessCell DifferentiationNeurogenesisOrgan DevelopmentTissue DevelopmentMetabolic ProcessPrimary Metabolic ProcessCellular Metabolic ProcessCellular ProcessNegative Regulation Of Cellular ProcessNegative Regulation Of Biological ProcessSystem DevelopmentMacromolecule Metabolic ProcessMulticellular Organismal DevelopmentAnatomical Structure DevelopmentDevelopmental ProcessCellular Macromolecule Metabolic ProcessAnatomical Structure MorphogenesisRegulation Of Multicellular Organismal ProcessResponse To StressNervous System DevelopmentResponse To External StimulusGeneration Of NeuronsRegulation Of Metabolic ProcessRegulation Of Developmental ProcessCellular Developmental ProcessNeuron DifferentiationCentral Nervous System DevelopmentRegulation Of Cellular Metabolic ProcessRegulation Of Cell DifferentiationGrowthResponse To WoundingBiological RegulationRegulation Of Macromolecule Metabolic ProcessNegative Regulation Of Developmental ProcessCell Fate CommitmentRegulation Of Primary Metabolic ProcessRegulation Of Biological ProcessForebrain DevelopmentBiosynthetic ProcessNeuron Fate CommitmentMulticellular Organismal ProcessResponse To StimulusCellular Biosynthetic ProcessBrain DevelopmentNegative Regulation Of Cell DifferentiationRegulation Of Cellular ProcessNitrogen Compound Metabolic ProcessRegenerationRegulation Of Cell DevelopmentCellular Nitrogen Compound Metabolic ProcessDevelopmental GrowthCellular CompartmentNucleusIntracellular PartIntracellularMembrane-bounded OrganelleIntracellular Membrane-bounded OrganelleOrganelleIntracellular OrganelleIntegral To Plasma MembraneIntrinsic To Plasma MembranePlasma Membrane PartMolecular FunctionProtein BindingPathwaysPantherAngiogenesisAlzheimer Disease-presenilin PathwayDiseaseStrokeTissueBrain

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BACKGROUND

This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). [provided by RefSeq].

REFERENCES

Liu, H., et al. Circ. Res. 107(7):860-870(2010)
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Menon, S., et al. Cephalalgia (2010) In press :
Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :
Johnatty, S.E., et al. PLoS Genet. 6 (7), E1001016 (2010) :