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NOTCH3 Antibody (C-term Q2306)Mouse Monoclonal Antibody (Mab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AM2059b | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
| AM2059b-ev20 | 20 ug 100 ul | In Stock | $ 95.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
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NOTCH3 Antibody (C-term Q2306) - Product info | |
| Application | WB
|
| Primary Accession | Q9UM47 |
| Other Accession | NP_000426.2 |
| Reactivity | Human |
| Concentration | 0.25 mg/ml |
| Isotype | IgG1 |
| Clone Names | 487CT6.9.2 |
| Calculated MW | 243631 Da |
NOTCH3 Antibody (C-term Q2306) - Additional info | |
| Gene ID 4854 | |
| Other Names NOTCH3; Neurogenic locus notch homolog protein 3; Notch 3 extracellular truncation; Notch 3 intracellular domain | |
| Target/Specificity This NOTCH3 Monoclonal antibody is generated from mouses immunized with a KLH conjugated synthetic peptide selected from the C-term region of human NOTCH3. | |
| Dilution WB~~1:100~250 | |
| Format Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions NOTCH3 Antibody (C-term Q2306) is for research use only and not for use in diagnostic or therapeutic procedures. | |
NOTCH3 Antibody (C-term Q2306) - Protein Information | |
| Name NOTCH3 | |
| Function Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity) | |
| Cellular Location Cell membrane; Single-pass type I membrane protein | |
| Tissue Location Ubiquitously expressed in fetal and adult tissues | |
NOTCH3 Antibody (C-term Q2306) - Related products
AM2059a: NOTCH3 Antibody (C-term Q2306) (Ascites)
AM2059b: NOTCH3 Antibody (C-term Q2306)
AP6220a: NOTCH3 Antibody (C-term)
NOTCH3 Antibody (C-term Q2306) - Application data
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NOTCH3 Antibody (Q2306) (Cat. #AM2059b) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the NOTCH3 antibody detected the NOTCH3 protein (arrow).
NOTCH3 Antibody (C-term Q2306) - Research Areas
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BACKGROUND
This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). [provided by RefSeq].
REFERENCES
Liu, H., et al. Circ. Res. 107(7):860-870(2010) Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010) Menon, S., et al. Cephalalgia (2010) In press : Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) : Johnatty, S.E., et al. PLoS Genet. 6 (7), E1001016 (2010) :
