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IGF2 Antibody

Mouse Monoclonal Antibody (Mab)

     
  • WB - IGF2 Antibody AM2070b
    IGF2 Antibody (Cat. #AM2070b) western blot analysis in A549 cell line lysates (35μg/lane).This demonstrates the IGF2 antibody detected the IGF2 protein (arrow).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession P01344
Other Accession NP_000603.1
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgM
Clone/Animal Names 519CT14.3.6
Calculated MW 20140 Da
Antigen Region 39-68 aa
Additional Information
Gene ID 3481
Other Names Insulin-like growth factor II, IGF-II, Somatomedin-A, Insulin-like growth factor II, Insulin-like growth factor II Ala-25 Del, Preptin, IGF2
Target/Specificity This IGF2 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 39-68 amino acids from human IGF2.
Dilution WB~~1:500~1000
Format Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Euglobin precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsIGF2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name IGF2
Function The insulin-like growth factors possess growth-promoting activity (By similarity). Major fetal growth hormone in mammals. Plays a key role in regulating fetoplacental development. IGF2 is influenced by placental lactogen. Also involved in tissue differentiation. In adults, involved in glucose metabolism in adipose tissue, skeletal muscle and liver (Probable). Acts as a ligand for integrin which is required for IGF2 signaling (PubMed:28873464). Positively regulates myogenic transcription factor MYOD1 function by facilitating the recruitment of transcriptional coactivators, thereby controlling muscle terminal differentiation (By similarity). Inhibits myoblast differentiation and modulates metabolism via increasing the mitochondrial respiration rate (By similarity).
Cellular Location Secreted.
Tissue Location Expressed in heart, placenta, lung, liver, muscle, kidney, tongue, limb, eye and pancreas.
Research Areas
Citations (0)
citation

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Background

This gene encodes a member of the insulin family of polypeptide growth factors, which are involved in development and growth. It is an imprinted gene, expressed only from the paternal allele, and epigenetic changes at this locus are associated with Wilms tumour, Beckwith-Wiedemann syndrome, rhabdomyosarcoma, and Silver-Russell syndrome. A read-through INS-IGF2 gene exists, whose 5' region overlaps the INS gene and the 3' region overlaps this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

References

Adkins, R.M., et al. Pediatr. Res. 68(5):429-434(2010)
Romero, R., et al. Am. J. Obstet. Gynecol. 203 (4), 361 (2010) :
Li, J., et al. Mol. Biol. Rep. (2010) In press :
Hsieh, Y.Y., et al. Anticancer Res. 30(6):2203-2208(2010)
Turan, N., et al. PLoS Genet. 6 (7), E1001033 (2010) :

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Discontinued
Cat# AM2070b
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