|Application ||WB, E|
|Calculated MW||32177 Da|
|Antigen Region||34-64 aa|
|Other Names||Cyclin-dependent kinase inhibitor 1C, Cyclin-dependent kinase inhibitor p57, p57Kip2, CDKN1C, KIP2|
|Target/Specificity||This CDKN1C antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 34-64 amino acids from human CDKN1C.|
|Format||Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Euglobin precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CDKN1C Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non- proliferative state throughout life.|
|Tissue Location||Expressed in the heart, brain, lung, skeletal muscle, kidney, pancreas and testis. Expressed in the eye. High levels are seen in the placenta while low levels are seen in the liver.|
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Provided below are standard protocols that you may find useful for product applications.
This gene is imprinted, with preferential expression of the maternal allele. The encoded protein is a tight-binding, strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene.
O'Seaghdha, C.M., et al. Hum. Mol. Genet. 19(21):4296-4303(2010)
Madhavan, J., et al. Ophthalmic Genet. 31(3):141-146(2010)
Romanelli, V., et al. Am. J. Med. Genet. A 152A (6), 1390-1397 (2010) :
Hoffner, L., et al. J Reprod Med 55 (5-6), 219-228 (2010) :
Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :
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