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FMR1 Antibody (Ascites)

Mouse Monoclonal Antibody (Mab)

  • WB - FMR1 Antibody (Ascites) AM2076a
    FMR1 Antibody (Cat. #AM2076a) western blot analysis in Hela cell line lysates (35μg/lane).This demonstrates the FMR1 antibody detected the FMR1 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q06787
Other Accession NP_001172004.1
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgM
Clone Names 508CT17.2.2
Calculated MW 71174 Da
Antigen Region 20-48 aa
Additional Information
Gene ID 2332
Other Names Fragile X mental retardation protein 1, FMRP, Protein FMR-1, FMR1
Target/Specificity This FMR1 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 20-48 amino acids from human FMR1.
Dilution WB~~1:500~8000
Format Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsFMR1 Antibody (Ascites) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FMR1
Function Translation repressor. Component of the CYFIP1-EIF4E- FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates translation repression (By similarity). RNA- binding protein that plays a role in intracellular RNA transport and in the regulation of translation of target mRNAs. Associated with polysomes. May play a role in the transport of mRNA from the nucleus to the cytoplasm. Binds strongly to poly(G), binds moderately to poly(U) but shows very little binding to poly(A) or poly(C).
Cellular Location Cytoplasm. Nucleus, nucleolus.
Tissue Location Highest levels found in neurons, brain, testis, placenta and lymphocytes. Also expressed in epithelial tissues and at very low levels in glial cells
Research Areas
Citations (0)

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The protein encoded by this gene binds RNA and is associated with polysomes. The encoded protein may be involved in mRNA trafficking from the nucleus to the cytoplasm. A trinucleotide repeat (CGG) in the 5' UTR is normally found at 6-53 copies, but an expansion to 55-230 repeats is the cause of fragile X syndrome. Expansion of the trinucleotide repeat may also cause one form of premature ovarian failure (POF1). Multiple alternatively spliced transcript variants that encode different protein isoforms and which are located in different cellular locations have been described for this gene.


Rodriguez-Revenga, L., et al. Neurology 75(15):1370-1376(2010)
Lachiewicz, A., et al. J Intellect Disabil Res 54(7):597-610(2010)
Sittler, A., et al. Hum. Mol. Genet. 5(1):95-102(1996)
Verkerk, A.J., et al. Hum. Mol. Genet. 2 (8), 1348 (1993) :
Ashley, C.T., et al. Nat. Genet. 4(3):244-251(1993)

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Cat# AM2076a
(40 western blots)
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