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HMG2 Antibody (Ascites)
Mouse Monoclonal Antibody (Mab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P52926 |
| Other Accession | P52927, NP_003474.1 |
| Reactivity | Human |
| Predicted | Mouse |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG2b |
| Clone/Animal Names | 523ct16.1.1 |
| Calculated MW | 11832 Da |
| Antigen Region | 64-92 aa |
| Gene ID | 8091 |
|---|---|
| Other Names | High mobility group protein HMGI-C, High mobility group AT-hook protein 2, HMGA2, HMGIC |
| Target/Specificity | This HMG2 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 64-92 amino acids from human HMG2. |
| Dilution | WB~~1:500~8000 |
| Format | Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | HMG2 Antibody (Ascites) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | HMGA2 |
|---|---|
| Synonyms | HMGIC |
| Function | Functions as a transcriptional regulator. Functions in cell cycle regulation through CCNA2. Plays an important role in chromosome condensation during the meiotic G2/M transition of spermatocytes. Plays a role in postnatal myogenesis, is involved in satellite cell activation (By similarity). Positively regulates IGF2 expression through PLAG1 and in a PLAG1-independent manner (PubMed:28796236). |
| Cellular Location | Nucleus. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a protein that belongs to the non-histone chromosomal high mobility group (HMG) protein family. HMG proteins function as architectural factors and are essential components of the enhancesome. This protein contains structural DNA-binding domains and may act as a transcriptional regulating factor. Identification of the deletion, amplification, and rearrangement of this gene that are associated with myxoid liposarcoma suggests a role in adipogenesis and mesenchymal differentiation. A gene knock out study of the mouse counterpart demonstrated that this gene is involved in diet-induced obesity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
References
Markowski, D.N., et al. Cancer Genet. Cytogenet. 202(1):53-57(2010)
Velagaleti, G.V., et al. Cancer Genet. Cytogenet. 202(1):11-16(2010)
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Liu, Y., et al. Carcinogenesis 31(10):1762-1769(2010)
Voight, B.F., et al. Nat. Genet. 42(7):579-589(2010)
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