|Application ||WB, E|
|Calculated MW||53588 Da|
|Antigen Region||408-439 aa|
|Other Names||Arylsulfatase A, ASA, Cerebroside-sulfatase, Arylsulfatase A component B, Arylsulfatase A component C, ARSA|
|Target/Specificity||This ARSA antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 408-439 amino acids from the C-terminal region of human ARSA.|
|Format||Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ARSA Antibody (C-term) (Ascites) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Hydrolyzes cerebroside sulfate.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene hydrolyzes cerebroside sulfate to cerebroside and sulfate. Defects in this gene lead to metachromatic leucodystrophy (MLD), a progressive demyelination disease which results in a variety of neurological symptoms and ultimately death. Alternatively spliced transcript variants have been described for this gene.
Cesani, M., et al. Hum. Mutat. 30 (10), E936-E945 (2009) :
Matzner, U., et al. J. Biol. Chem. 284(14):9372-9381(2009)
Bisgaard, A.M., et al. Clin. Genet. 75(2):175-179(2009)
Lugowska, A., et al. Clin. Genet. 75(1):57-64(2009)
Oshikawa, M., et al. Mol. Vis. 15, 482-494 (2009) :
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