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ARSA Antibody (C-term)
Mouse Monoclonal Antibody (Mab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P15289 |
| Other Accession | NP_000478.2 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG2a |
| Clone/Animal Names | 498CT24.1.2 |
| Calculated MW | 53588 Da |
| Antigen Region | 408-439 aa |
| Gene ID | 410 |
|---|---|
| Other Names | Arylsulfatase A, ASA, Cerebroside-sulfatase, Arylsulfatase A component B, Arylsulfatase A component C, ARSA |
| Target/Specificity | This ARSA antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 408-439 amino acids from the C-terminal region of human ARSA. |
| Dilution | WB~~1:500~1000 |
| Format | Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ARSA Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ARSA |
|---|---|
| Function | Hydrolyzes cerebroside sulfate. |
| Cellular Location | Endoplasmic reticulum. Lysosome |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene hydrolyzes cerebroside sulfate to cerebroside and sulfate. Defects in this gene lead to metachromatic leucodystrophy (MLD), a progressive demyelination disease which results in a variety of neurological symptoms and ultimately death. Alternatively spliced transcript variants have been described for this gene.
References
Cesani, M., et al. Hum. Mutat. 30 (10), E936-E945 (2009) : Matzner, U., et al. J. Biol. Chem. 284(14):9372-9381(2009) Bisgaard, A.M., et al. Clin. Genet. 75(2):175-179(2009) Lugowska, A., et al. Clin. Genet. 75(1):57-64(2009) Oshikawa, M., et al. Mol. Vis. 15, 482-494 (2009) :
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