|Application ||WB, E|
|Other Accession||P79338, P03180, NP_000563.1|
|Calculated MW||20517 Da|
|Antigen Region||27-53 aa|
|Other Names||Interleukin-10, IL-10, Cytokine synthesis inhibitory factor, CSIF, IL10|
|Target/Specificity||This IL10 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 27-53 amino acids from human IL10.|
|Format||Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||IL10 Antibody(Ascites) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells.|
|Tissue Location||Produced by a variety of cell lines, including T-cells, macrophages, mast cells and other cell types|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. [provided by RefSeq].
Huebinger, R.M., et al. J. Surg. Res. 164 (1), E141-E145 (2010) :
Glocker, E.O., et al. Lancet 376 (9748), 1272 (2010) :
Mosaad, Y.M., et al. Scand. J. Immunol. 72(4):358-364(2010)
Kung, W.J., et al. Diabetes Technol. Ther. 12(10):809-813(2010)
Santhosh, S., et al. Trop Gastroenterol 31(1):30-33(2010)
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at firstname.lastname@example.org.