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TNFRSF8/CD30 Antibody (Center) (Ascites)
Mouse Monoclonal Antibody (Mab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P28908 |
| Other Accession | NP_001234.2 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Clone/Animal Names | 595CT15.5.1 |
| Calculated MW | 63747 Da |
| Antigen Region | 294-321 aa |
| Gene ID | 943 |
|---|---|
| Other Names | Tumor necrosis factor receptor superfamily member 8, CD30L receptor, Ki-1 antigen, Lymphocyte activation antigen CD30, CD30, TNFRSF8, CD30, D1S166E |
| Target/Specificity | This TNFRSF8/CD30 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 294-321 amino acids from the Central region of human TNFRSF8/CD30. |
| Dilution | WB~~1:100~1000 |
| Format | Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | TNFRSF8/CD30 Antibody (Center) (Ascites) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TNFRSF8 (HGNC:11923) |
|---|---|
| Function | Receptor for TNFSF8/CD30L (PubMed:8391931). May play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Regulates gene expression through activation of NF-kappa- B (PubMed:8999898). |
| Cellular Location | [Isoform 1]: Cell membrane; Single-pass type I membrane protein |
| Tissue Location | [Isoform 2]: Detected in alveolar macrophages (at protein level). |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
References
de Kleer, I., et al. J. Immunol. 185(4):2071-2079(2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Halim, M.A., et al. Transplant. Proc. 42(3):801-803(2010)
Dong, L., et al. J. Biomed. Biotechnol. 2010, 569053 (2010) :
Kamali, K., et al. Exp Clin Transplant 7(4):237-240(2009)
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