|Application ||WB, E|
|Calculated MW||33806 Da|
|Antigen Region||279-308 aa|
|Other Names||Hydroxyacylglutathione hydrolase, mitochondrial, Glyoxalase II, Glx II, HAGH, GLO2, HAGH1|
|Target/Specificity||This HAGH antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 279-308 amino acids from the C-terminal region of human HAGH.|
|Format||Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||HAGH Antibody (C-term) (Ascites) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid.|
|Cellular Location||Isoform 1: Mitochondrion matrix|
|Tissue Location||Expressed in liver and kidney.|
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Provided below are standard protocols that you may find useful for product applications.
The enzyme encoded by this gene is classified as a thiolesterase and is responsible for the hydrolysis of S-lactoyl-glutathione to reduced glutathione and D-lactate. Two transcript variants encoding different isoforms have been found for this gene.
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Limphong, P., et al. Biochemistry 48(23):5426-5434(2009)
Antognelli, C., et al. Cancer Biol. Ther. 6(12):1880-1888(2007)
Xu, Y., et al. J. Biol. Chem. 281(36):26702-26713(2006)
Antognelli, C., et al. Cancer J 12(3):222-228(2006)
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