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lgA Antibody (Center) (Ascites)

Mouse Monoclonal Antibody (Mab)

     
  • WB - lgA Antibody (Center) (Ascites) AM2162a
    lgA Antibody (Center)(Ascites)(Cat. #AM2162a) western blot analysis in CEM cell line lysates (35μg/lane).This demonstrates the lgA antibody detected the lgA protein (arrow).
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession P01876
Other Accession P01877
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgM
Clone/Animal Names 585CT26.3.1
Calculated MW 42849 Da
Antigen Region 150-178 aa
Additional Information
Other Names Ig alpha-1 chain C region, IGHA1
Target/Specificity This lgA antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 150-178 amino acids from the Central region of human lgA.
Dilution WB~~1:100~1600
Format Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionslgA Antibody (Center) (Ascites) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name IGHA1 {ECO:0000303|PubMed:11340299, ECO:0000303|Ref.13}
Function Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins- secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). Ig alpha is the major immunoglobulin class in body secretions (PubMed:2241915).
Cellular Location [Isoform 1]: Secreted
Research Areas
Citations (0)
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Background

Ig alpha is the major immunoglobulin class in body secretions. It may serve both to defend against local infection and to prevent access of foreign antigens to the general immunologic system.

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$ 365.00
Cat# AM2162a
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