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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   COMT Antibody (N-term) (Ascites)   

COMT Antibody (N-term) (Ascites)

Mouse Monoclonal Antibody (Mab)

  • WB - COMT Antibody (N-term) (Ascites) AM2164a
    COMT Antibody (N-term)(Ascites)(Cat. #AM2164a) western blot analysis in Hela cell line lysates (35μg/lane).This demonstrates the COMT antibody detected the COMT protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P21964
Other Accession NP_000745.1
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG1
Clone Names 630CT1.7.1
Calculated MW 30037 Da
Antigen Region 37-65 aa
Additional Information
Gene ID 1312
Other Names Catechol O-methyltransferase, COMT
Target/Specificity This COMT antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 37-65 amino acids from the N-terminal region of human COMT.
Dilution WB~~1:100~400
Format Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCOMT Antibody (N-term) (Ascites) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Function Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.
Cellular Location Isoform Soluble: Cytoplasm.
Tissue Location Brain, liver, placenta, lymphocytes and erythrocytes
Research Areas
Citations (0)

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Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters.


Paloyelis, Y., et al. Neuropsychopharmacology 35(12):2414-2426(2010)
Stroth, S., et al. Neurobiol Learn Mem 94(3):364-372(2010)
Lim, J.H., et al. Pharmacogenet. Genomics 20(10):605-610(2010)
Demetrovics, Z., et al. Compr Psychiatry 51(5):510-515(2010)
Bodenmann, S., et al. Sleep 33(8):1027-1035(2010)

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$ 295.00
Cat# AM2164a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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