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DRD4 Antibody (Center) (Ascites)

Mouse Monoclonal Antibody (Mab)

  • WB - DRD4 Antibody (Center) (Ascites) AM2167a
    DRD4 Antibody (Center)(Ascites)(Cat. #AM2167a) western blot analysis in mouse heart cell line lysates (35μg/lane).This demonstrates the DRD4 antibody detected the DRD4 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P21917
Other Accession NP_000788.2
Reactivity Human, Mouse
Host Mouse
Clonality Monoclonal
Isotype IgG1
Clone Names 625CT1.5.4
Calculated MW 48361 Da
Antigen Region 365-391 aa
Additional Information
Gene ID 1815
Other Names D(4) dopamine receptor, D(2C) dopamine receptor, Dopamine D4 receptor, DRD4
Target/Specificity This DRD4 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 365-391 amino acids from the Central region of human DRD4.
Dilution WB~~1:500~8000
Format Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsDRD4 Antibody (Center) (Ascites) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name DRD4
Function Dopamine receptor responsible for neuronal signaling in the mesolimbic system of the brain, an area of the brain that regulates emotion and complex behavior. Its activity is mediated by G proteins which inhibit adenylyl cyclase. Modulates the circadian rhythm of contrast sensitivity by regulating the rhythmic expression of NPAS2 in the retinal ganglion cells (By similarity).
Cellular Location Cell membrane; Multi-pass membrane protein
Research Areas
Citations (0)

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This gene encodes the D4 subtype of the dopamine receptor. The D4 subtype is a G-protein coupled receptor which inhibits adenylyl cyclase. It is a target for drugs which treat schizophrenia and Parkinson disease. Mutations in this gene have been associated with various behavioral phenotypes, including autonomic nervous system dysfunction, attention deficit/hyperactivity disorder, and the personality trait of novelty seeking. This gene contains a polymorphic number (2-10 copies) of tandem 48 nt repeats; the sequence shown contains four repeats.


Lai, J.H., et al. Brain Res. 1359, 227-232 (2010) :
Paloyelis, Y., et al. Neuropsychopharmacology 35(12):2414-2426(2010)
Gadow, K.D., et al. Eur. J. Neurosci. 32(6):1058-1065(2010)
Szekely, A., et al. Genes Brain Behav. (2010) In press :
Chio, C.L., et al. J. Biol. Chem. 269(16):11813-11819(1994)

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$ 295.00
Cat# AM2167a
(40 western blots)
Availability: In Stock
Bulk Size
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