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>   home   >   Products   >   Primary Antibodies   >   Neuroscience   >   ACHE Antibody (C-term) (Ascites)   

ACHE Antibody (C-term) (Ascites)

Mouse Monoclonal Antibody (Mab)

  • WB - ACHE Antibody (C-term) (Ascites) AM2184a
    ACHE Antibody (C-term) (Cat. #AM2184a) western blot analysis in NCI-H460 cell line lysates (35μg/lane).This demonstrates the ACHE antibody detected the ACHE protein (arrow).
  • WB - ACHE Antibody (C-term) (Ascites) AM2184a
    ACHE Antibody (C-term) (Cat. #AM2184a) western blot analysis in CHO cell line lysates (35μg/lane).This demonstrates the ACHE antibody detected the ACHE protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P22303
Other Accession Q29499, P23795, NP_000656
Reactivity Human, Hamster
Predicted Bovine, Rabbit
Host Mouse
Clonality Monoclonal
Isotype IgG1
Clone Names 684CT8.3.4
Calculated MW 67796 Da
Antigen Region 582-610 aa
Additional Information
Gene ID 43
Other Names Acetylcholinesterase, AChE, ACHE
Target/Specificity This ACHE antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 582-610 amino acids from the C-terminal region of human ACHE.
Dilution WB~~1:200~3200
Format Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsACHE Antibody (C-term) (Ascites) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Function Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. Role in neuronal apoptosis.
Cellular Location Cell junction, synapse Secreted. Cell membrane; Peripheral membrane protein Isoform H: Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side
Tissue Location Isoform H is highly expressed in erythrocytes.
Research Areas
Citations (0)

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Acetylcholinesterase hydrolyzes the neurotransmitter, acetylcholine at neuromuscular junctions and brain cholinergic synapses, and thus terminates signal transmission. It is also found on the red blood cell membranes, where it constitutes the Yt blood group antigen. Acetylcholinesterase exists in multiple molecular forms which possess similar catalytic properties, but differ in their oligomeric assembly and mode of cell attachment to the cell surface. It is encoded by the single ACHE gene, and the structural diversity in the gene products arises from alternative mRNA splicing, and post-translational associations of catalytic and structural subunits. The major form of acetylcholinesterase found in brain, muscle and other tissues is the hydrophilic species, which forms disulfide-linked oligomers with collagenous, or lipid-containing structural subunits. The other, alternatively spliced form, expressed primarily in the erythroid tissues, differs at the C-terminal end, and contains a cleavable hydrophobic peptide with a GPI-anchor site. It associates with the membranes through the phosphoinositide (PI) moieties added post-translationally.


Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Howard, T.D., et al. Environ. Health Perspect. 118(10):1395-1399(2010)
Cadieux, C.L., et al. Chem. Biol. Interact. 187 (1-3), 229-233 (2010) :
Ruano, G., et al. Pharmacogenomics 11(7):959-971(2010)
Ohno, K., et al. Proc. Natl. Acad. Sci. U.S.A. 95(16):9654-9659(1998)

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$ 295.00
Cat# AM2184a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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