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FN3K Antibody (N-term)(Ascites)
Mouse Monoclonal Antibody (Mab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9H479 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Clone/Animal Names | 788CT24.5.1 |
| Calculated MW | 35171 Da |
| Gene ID | 64122 |
|---|---|
| Other Names | Fructosamine-3-kinase, 271-, FN3K |
| Target/Specificity | Purified His-tagged FN3K protein was used to produced this monoclonal antibody. |
| Dilution | WB~~1:1000~8000 |
| Format | Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | FN3K Antibody (N-term)(Ascites) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | FN3K {ECO:0000303|PubMed:14633848, ECO:0000312|HGNC:HGNC:24822} |
|---|---|
| Function | Fructosamine-3-kinase involved in protein deglycation by mediating phosphorylation of fructoselysine residues on glycated proteins, to generate fructoselysine-3 phosphate (PubMed:11016445, PubMed:11522682, PubMed:11975663). Fructoselysine-3 phosphate adducts are unstable and decompose under physiological conditions (PubMed:11522682, PubMed:11975663). Involved in intracellular deglycation in erythrocytes (PubMed:11975663). Involved in the response to oxidative stress by mediating deglycation of NFE2L2/NRF2, glycation impairing NFE2L2/NRF2 function (By similarity). Also able to phosphorylate psicosamines and ribulosamines (PubMed:14633848). |
| Tissue Location | Widely expressed (PubMed:11522682). Expressed in erythrocytes (PubMed:11016445). |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
May initiate a process leading to the deglycation of fructoselysine and of glycated proteins. May play a role in the phosphorylation of 1-deoxy-1-morpholinofructose (DMF), fructoselysine, fructoseglycine, fructose and glycated lysozyme.
References
Delpierre G., et al. Diabetes 49:1627-1634(2000).
Yu L.-R., et al. J. Proteome Res. 6:4150-4162(2007).
Burkard T.R., et al. BMC Syst. Biol. 5:17-17(2011).
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