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MBD3 Antibody (C-term)

Mouse Monoclonal Antibody (Mab)

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  • WB - MBD3 Antibody (C-term) AM2203b
    MBD3 Antibody (C-term) (Cat. #AM2203b) western blot analysis in K562 cell line lysates (35μg/lane).This demonstrates the MBD3 antibody detected the MBD3 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O95983
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG1
Clone Names 995CT3.2.2
Calculated MW 32844 Da
Additional Information
Gene ID 53615
Other Names Methyl-CpG-binding domain protein 3, Methyl-CpG-binding protein MBD3, MBD3
Target/Specificity Purified His-tagged MBD3 protein was used to produced this monoclonal antibody.
Dilution WB~~1:1000
Format Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMBD3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MBD3
Function Acts as transcriptional repressor and plays a role in gene silencing. Does not bind to DNA by itself (PubMed:12124384). Binds to DNA with a preference for sites containing methylated CpG dinucleotides (in vitro). Binds to a lesser degree DNA containing unmethylated CpG dinucleotides (PubMed:24307175). Recruits histone deacetylases and DNA methyltransferases.
Cellular Location Nucleus. Chromosome. Note=Nuclear, in discrete foci. Detected on chromatin, at promoter regions of active genes
Research Areas
Citations (0)

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Does not bind DNA by itself. Recruits histone deacetylases and DNA methyltransferases. Acts as transcriptional repressor and plays a role in gene silencing.


Hendrich B., et al. Mol. Cell. Biol. 18:6538-6547(1998).
Ota T., et al. Nat. Genet. 36:40-45(2004).
Grimwood J., et al. Nature 428:529-535(2004).
Mural R.J., et al. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Tatematsu K., et al. Genes Cells 5:677-688(2000).

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$ 295.00
$ 99.00
Cat# AM2203b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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