|Application ||WB, E|
|Calculated MW||59961 Da|
|Other Names||Ubiquitin carboxyl-terminal hydrolase 22, Deubiquitinating enzyme 22, Ubiquitin thioesterase 22, Ubiquitin-specific-processing protease 22, USP22, KIAA1063, USP3L|
|Target/Specificity||Purified His-tagged USP22 protein was used to produced this monoclonal antibody.|
|Format||Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||USP22 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA. Catalyzes the deubiquitination of both histones H2A and H2B, thereby acting as a coactivator. Recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation and cell cycle progression.|
|Tissue Location||Moderately expressed in various tissues including heart and skeletal muscle, and weakly expressed in lung and liver.|
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Provided below are standard protocols that you may find useful for product applications.
Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA. Catalyzes the deubiquitination of both histones H2A and H2B, thereby acting as a coactivator. Recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation and cell cycle progression.
Kikuno R., et al. DNA Res. 6:197-205(1999).
Bechtel S., et al. BMC Genomics 8:399-399(2007).
Lee H.-J., et al. Gene Expr. Patterns 6:277-284(2006).
Zhao Y., et al. Mol. Cell 29:92-101(2008).
Zhang X.-Y., et al. Mol. Cell 29:102-111(2008).
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